LMPD Database

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LMP000428

UniProt Annotations

Entry Information
Gene Namestearoyl-Coenzyme A desaturase 1
Protein EntryACOD1_MOUSE
UniProt IDP13516
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityStearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875;
DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding.
FunctionTerminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.
SimilarityBelongs to the fatty acid desaturase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:16275639}; Multi-pass membrane protein {ECO:0000269|PubMed:16275639}.