LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP000396

UniProt Annotations

Entry Information
Gene Nameprotein kinase, cAMP dependent regulatory, type II beta
Protein EntryKAP3_MOUSE
UniProt IDP31324
SpeciesMouse
Comments
Comment typeDescription
FunctionRegulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
InteractionQ5S006:Lrrk2; NbExp=3; IntAct=EBI-455340, EBI-2693710; P05132:Prkaca; NbExp=3; IntAct=EBI-455340, EBI-400564;
PtmPhosphorylated by the activated catalytic chain. {ECO:0000269|PubMed:16452087, ECO:0000269|PubMed:17242355, ECO:0000269|PubMed:19131326}.
SimilarityBelongs to the cAMP-dependent kinase regulatory chain family. {ECO:0000305}.
SimilarityContains 2 cyclic nucleotide-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00060}.
Subcellular LocationCytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane. {ECO:0000250}.
SubunitThe inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with the phosphorylated form of PJA2 (By similarity). {ECO:0000250}.
Tissue SpecificityFour types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.