LMPD Database

LMP000386

Gene Information

Entrez Gene ID	348
Gene Name	apolipoprotein E
Gene Symbol	APOE
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0072562	IDA:UniProt	C	blood microparticle
GO:0042627	IDA:BHF-UCL	C	chylomicron
GO:0005737	TAS:UniProtKB	C	cytoplasm
GO:0030425	NAS:BHF-UCL	C	dendrite
GO:0005769	TAS:Reactome	C	early endosome
GO:0071682	TAS:Reactome	C	endocytic vesicle lumen
GO:0031012	IDA:UniProtKB	C	extracellular matrix
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	IDA:BHF-UCL	C	extracellular space
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0031232	IEA:Ensembl	C	extrinsic component of external side of plasma membrane
GO:0005794	IEA:Ensembl	C	Golgi apparatus
GO:0034364	IDA:BHF-UCL	C	high-density lipoprotein particle
GO:0034363	IDA:BHF-UCL	C	intermediate-density lipoprotein particle
GO:0005770	IEA:Ensembl	C	late endosome
GO:0034362	IDA:BHF-UCL	C	low-density lipoprotein particle
GO:0016020	IDA:UniProtKB	C	membrane
GO:0043025	NAS:BHF-UCL	C	neuronal cell body
GO:0005634	IDA:UniProt	C	nucleus
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0034361	IDA:BHF-UCL	C	very-low-density lipoprotein particle
GO:0031982	IDA:UniProtKB	C	vesicle
GO:0016209	IDA:BHF-UCL	F	antioxidant activity
GO:0001540	IDA:UniProtKB	F	beta-amyloid binding
GO:0017127	IEA:Ensembl	F	cholesterol transporter activity
GO:0008201	IDA:BHF-UCL	F	heparin binding
GO:0046848	IEA:Ensembl	F	hydroxyapatite binding
GO:0042802	IDA:BHF-UCL	F	identical protein binding
GO:0008289	IDA:UniProtKB	F	lipid binding
GO:0005319	IDA:BHF-UCL	F	lipid transporter activity
GO:0071813	IEA:Ensembl	F	lipoprotein particle binding
GO:0050750	IDA:BHF-UCL	F	low-density lipoprotein particle receptor binding
GO:0046911	IDA:BHF-UCL	F	metal chelating activity
GO:0060228	IDA:BHF-UCL	F	phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0005543	IDA:BHF-UCL	F	phospholipid binding
GO:0042803	IPI:BHF-UCL	F	protein homodimerization activity
GO:0048156	IPI:BHF-UCL	F	tau protein binding
GO:0070326	IDA:BHF-UCL	F	very-low-density lipoprotein particle receptor binding
GO:0007568	IEA:Ensembl	P	aging
GO:0097113	IDA:Alzheimers_University_of_Toronto	P	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0048844	IEA:Ensembl	P	artery morphogenesis
GO:0008219	IEA:UniProtKB-KW	P	cell death
GO:0006874	IEA:Ensembl	P	cellular calcium ion homeostasis
GO:0071397	IEA:Ensembl	P	cellular response to cholesterol
GO:0071363	IEA:Ensembl	P	cellular response to growth factor stimulus
GO:0071347	IEA:Ensembl	P	cellular response to interleukin-1
GO:0019934	IDA:BHF-UCL	P	cGMP-mediated signaling
GO:0006707	IEA:Ensembl	P	cholesterol catabolic process
GO:0033344	IDA:BHF-UCL	P	cholesterol efflux
GO:0042632	IDA:BHF-UCL	P	cholesterol homeostasis
GO:0008203	IDA:BHF-UCL	P	cholesterol metabolic process
GO:0034382	IMP:BHF-UCL	P	chylomicron remnant clearance
GO:0007010	TAS:UniProtKB	P	cytoskeleton organization
GO:0055089	IDA:Alzheimers_University_of_Toronto	P	fatty acid homeostasis
GO:0007186	IDA:BHF-UCL	P	G-protein coupled receptor signaling pathway
GO:0034380	IDA:BHF-UCL	P	high-density lipoprotein particle assembly
GO:0034384	IDA:BHF-UCL	P	high-density lipoprotein particle clearance
GO:0034375	IGI:BHF-UCL	P	high-density lipoprotein particle remodeling
GO:0046907	TAS:UniProtKB	P	intracellular transport
GO:0042158	IEA:Ensembl	P	lipoprotein biosynthetic process
GO:0042159	IEA:Ensembl	P	lipoprotein catabolic process
GO:0042157	TAS:Reactome	P	lipoprotein metabolic process
GO:0015909	IDA:Alzheimers_University_of_Toronto	P	long-chain fatty acid transport
GO:0034374	IEA:Ensembl	P	low-density lipoprotein particle remodeling
GO:0051651	IEA:Ensembl	P	maintenance of location in cell
GO:1902430	IDA:Alzheimers_University_of_Toronto	P	negative regulation of beta-amyloid formation
GO:0030195	IDA:BHF-UCL	P	negative regulation of blood coagulation
GO:0043537	IDA:BHF-UCL	P	negative regulation of blood vessel endothelial cell migration
GO:0045541	IDA:BHF-UCL	P	negative regulation of cholesterol biosynthetic process
GO:0090370	IDA:Alzheimers_University_of_Toronto	P	negative regulation of cholesterol efflux
GO:0061000	IDA:Alzheimers_University_of_Toronto	P	negative regulation of dendritic spine development
GO:1902951	IDA:Alzheimers_University_of_Toronto	P	negative regulation of dendritic spine maintenance
GO:0001937	IDA:BHF-UCL	P	negative regulation of endothelial cell proliferation
GO:0050728	IC:BHF-UCL	P	negative regulation of inflammatory response
GO:0051055	IDA:Alzheimers_University_of_Toronto	P	negative regulation of lipid biosynthetic process
GO:1903001	IDA:Alzheimers_University_of_Toronto	P	negative regulation of lipid transport across blood brain barrier
GO:0043407	IDA:BHF-UCL	P	negative regulation of MAP kinase activity
GO:0043524	IEA:Ensembl	P	negative regulation of neuron apoptotic process
GO:1901215	IDA:Alzheimers_University_of_Toronto	P	negative regulation of neuron death
GO:1902999	IDA:Alzheimers_University_of_Toronto	P	negative regulation of phospholipid efflux
GO:0010544	IDA:BHF-UCL	P	negative regulation of platelet activation
GO:1901627	IDA:Alzheimers_University_of_Toronto	P	negative regulation of postsynaptic membrane organization
GO:1901630	IDA:Alzheimers_University_of_Toronto	P	negative regulation of presynaptic membrane organization
GO:0007263	IDA:BHF-UCL	P	nitric oxide mediated signal transduction
GO:0097114	IDA:Alzheimers_University_of_Toronto	P	N-methyl-D-aspartate receptor clustering
GO:0048709	IEA:Ensembl	P	oligodendrocyte differentiation
GO:0014012	IEA:Ensembl	P	peripheral nervous system axon regeneration
GO:0033700	IDA:BHF-UCL	P	phospholipid efflux
GO:0007603	TAS:Reactome	P	phototransduction, visible light
GO:0045773	IEA:Ensembl	P	positive regulation of axon extension
GO:1902004	IDA:Alzheimers_University_of_Toronto	P	positive regulation of beta-amyloid formation
GO:0030828	IDA:BHF-UCL	P	positive regulation of cGMP biosynthetic process
GO:0010875	IDA:Alzheimers_University_of_Toronto	P	positive regulation of cholesterol efflux
GO:0010873	IDA:BHF-UCL	P	positive regulation of cholesterol esterification
GO:0060999	IDA:Alzheimers_University_of_Toronto	P	positive regulation of dendritic spine development
GO:1902952	IDA:Alzheimers_University_of_Toronto	P	positive regulation of dendritic spine maintenance
GO:0046889	IDA:Alzheimers_University_of_Toronto	P	positive regulation of lipid biosynthetic process
GO:1903002	IDA:Alzheimers_University_of_Toronto	P	positive regulation of lipid transport across blood brain barrier
GO:0032805	IDA:BHF-UCL	P	positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0051044	IDA:BHF-UCL	P	positive regulation of membrane protein ectodomain proteolysis
GO:1902998	IDA:Alzheimers_University_of_Toronto	P	positive regulation of neurofibrillary tangle assembly
GO:1901216	IDA:Alzheimers_University_of_Toronto	P	positive regulation of neuron death
GO:0051000	IDA:BHF-UCL	P	positive regulation of nitric-oxide synthase activity
GO:1902995	IDA:Alzheimers_University_of_Toronto	P	positive regulation of phospholipid efflux
GO:1901628	IDA:Alzheimers_University_of_Toronto	P	positive regulation of postsynaptic membrane organization
GO:1901631	IDA:Alzheimers_University_of_Toronto	P	positive regulation of presynaptic membrane organization
GO:0017038	IDA:Alzheimers_University_of_Toronto	P	protein import
GO:0006898	IDA:BHF-UCL	P	receptor-mediated endocytosis
GO:0030516	TAS:UniProtKB	P	regulation of axon extension
GO:1900221	IDA:Alzheimers_University_of_Toronto	P	regulation of beta-amyloid clearance
GO:0032489	IDA:BHF-UCL	P	regulation of Cdc42 protein signal transduction
GO:0048168	TAS:UniProtKB	P	regulation of neuronal synaptic plasticity
GO:1901214	IDA:Alzheimers_University_of_Toronto	P	regulation of neuron death
GO:1902947	IDA:Alzheimers_University_of_Toronto	P	regulation of tau-protein kinase activity
GO:0002021	IEA:Ensembl	P	response to dietary excess
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0032868	IEA:Ensembl	P	response to insulin
GO:0000302	NAS:UniProtKB	P	response to reactive oxygen species
GO:0032526	IEA:Ensembl	P	response to retinoic acid
GO:0001523	TAS:Reactome	P	retinoid metabolic process
GO:0043691	IDA:BHF-UCL	P	reverse cholesterol transport
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0007271	TAS:UniProtKB	P	synaptic transmission, cholinergic
GO:0006641	IDA:BHF-UCL	P	triglyceride metabolic process
GO:0042311	IEA:Ensembl	P	vasodilation
GO:0034447	IDA:BHF-UCL	P	very-low-density lipoprotein particle clearance
GO:0034372	IDA:BHF-UCL	P	very-low-density lipoprotein particle remodeling

KEGG Pathway Links

KEGG Pathway ID	Description
hsa05010	Alzheimer's disease

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_163699	Scavenging by Class A Receptors