LMPD Database

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LMP000381

UniProt Annotations

Entry Information
Gene Namephospholipid scramblase 1
Protein EntryPLS1_HUMAN
UniProt IDO15162
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15162-1; Sequence=Displayed; Name=2; IsoId=O15162-2; Sequence=VSP_055237, VSP_055238; Note=No experimental confirmation available.;
CofactorName=Ca(2+); Xref=ChEBI
DomainThe N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.
FunctionMay mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
FunctionMay play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.
InductionBy phosphorylation by PKC. Induced by IFNB1/IFN-beta in response to a viral infection.
InteractionQ9WMX2:- (xeno); NbExp=8; IntAct=EBI-740019, EBI-710918; Q16630:CPSF6; NbExp=2; IntAct=EBI-740019, EBI-358410; P09022:Hoxa1 (xeno); NbExp=3; IntAct=EBI-740019, EBI-3957603; Q8WWR8:NEU4; NbExp=2; IntAct=EBI-740019, EBI-746964; Q16625:OCLN; NbExp=2; IntAct=EBI-740019, EBI-2903088; Q92734:TFG; NbExp=2; IntAct=EBI-740019, EBI-357061;
SimilarityBelongs to the phospholipid scramblase family.
Subcellular LocationCell membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor; Cytoplasmic side. Nucleus.
SubunitInteracts with ABL.
Tissue SpecificityExpressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
Web ResourceName=Wikipedia; Note=Scramblase entry; URL="http://en.wikipedia.org/wiki/Scramblase";