LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP000369

UniProt Annotations

Entry Information
Gene Namelipase A, lysosomal acid, cholesterol esterase
Protein EntryLICH_HUMAN
UniProt IDP38571
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P38571-1; Sequence=Displayed; Name=2; IsoId=P38571-2; Sequence=VSP_018596, VSP_018597; Note=No experimental confirmation available.;
Catalytic ActivityA steryl ester + H(2)O = a sterol + a fatty acid.
DiseaseCholesteryl ester storage disease (CESD) [MIM
DiseaseWolman disease (WOD) [MIM
FunctionCrucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
SimilarityBelongs to the AB hydrolase superfamily. Lipase family.
Subcellular LocationLysosome.