LMPD Database

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LMP000367

UniProt Annotations

Entry Information
Gene Nameubiquitin protein ligase E3 component n-recognin 5
Protein EntryUBR5_HUMAN
UniProt IDO95071
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95071-1; Sequence=Displayed; Name=2; IsoId=O95071-2; Sequence=VSP_054399; Note=No experimental confirmation available.;
FunctionE3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'- linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. {ECO
InteractionP35222:CTNNB1; NbExp=6; IntAct=EBI-358329, EBI-491549; P49841:GSK3B; NbExp=8; IntAct=EBI-358329, EBI-373586; Q9BPZ3:PAIP2; NbExp=5; IntAct=EBI-358329, EBI-2957445;
MiscellaneousA cysteine residue is required for ubiquitin- thioester formation.
PathwayProtein modification; protein ubiquitination.
Sequence CautionSequence=BAA74919.3; Type=Erroneous initiation; Evidence= ;
SimilarityContains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
SimilarityContains 1 PABC domain. {ECO
SimilarityContains 1 UBR-type zinc finger. {ECO
Subcellular LocationNucleus.
SubunitBinds TOPBP1. Associates with CDK9 and TFIIS/TCEA1 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). Interacts directly with DYRK2. {ECO
Tissue SpecificityWidely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.