LMPD Database

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LMP000351

UniProt Annotations

Entry Information
Gene Namezinc finger, DHHC-type containing 17
Protein EntryZDH17_HUMAN
UniProt IDQ8IUH5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IUH5-1; Sequence=Displayed; Name=2; IsoId=Q8IUH5-2; Sequence=VSP_010021, VSP_010022, VSP_010024, VSP_010025; Name=3; IsoId=Q8IUH5-3; Sequence=VSP_010023; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.87 mM for for magnesium ions;
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DomainThe DHHC domain is required for palmitoyltransferase activity.
FunctionPalmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport. {ECO
InteractionSelf; NbExp=6; IntAct=EBI-524753, EBI-524753; Q7Z783:-; NbExp=3; IntAct=EBI-524753, EBI-9088990; Q7Z5R6:APBB1IP; NbExp=2; IntAct=EBI-524753, EBI-2818084; Q9NP61:ARFGAP3; NbExp=2; IntAct=EBI-524753, EBI-2875816; P15336:ATF2; NbExp=3; IntAct=EBI-524753, EBI-1170906; Q9UQB8-3:BAIAP2; NbExp=3; IntAct=EBI-524753, EBI-9091996; Q9UQB8-6:BAIAP2; NbExp=2; IntAct=EBI-524753, EBI-9092016; P17655:CAPN2; NbExp=2; IntAct=EBI-524753, EBI-1028956; Q96GN5-2:CDCA7L; NbExp=2; IntAct=EBI-524753, EBI-9091443; P48730-2:CSNK1D; NbExp=3; IntAct=EBI-524753, EBI-9087876; P68104:EEF1A1; NbExp=2; IntAct=EBI-524753, EBI-352162; P60228:EIF3E; NbExp=2; IntAct=EBI-524753, EBI-347740; Q9UI08-2:EVL; NbExp=2; IntAct=EBI-524753, EBI-6448852; Q9UHY8:FEZ2; NbExp=4; IntAct=EBI-524753, EBI-396453; Q08379:GOLGA2; NbExp=3; IntAct=EBI-524753, EBI-618309; Q9H4A5:GOLPH3L; NbExp=2; IntAct=EBI-524753, EBI-4403434; P51674:GPM6A; NbExp=5; IntAct=EBI-524753, EBI-7187133; P49840:GSK3A; NbExp=3; IntAct=EBI-524753, EBI-1044067; P42858:HTT; NbExp=12; IntAct=EBI-524753, EBI-466029; Q8IY31-3:IFT20; NbExp=3; IntAct=EBI-524753, EBI-9091197; Q9NWB7:IFT57; NbExp=2; IntAct=EBI-524753, EBI-725672; O60259:KLK8; NbExp=3; IntAct=EBI-524753, EBI-3915857; Q14847-2:LASP1; NbExp=3; IntAct=EBI-524753, EBI-9088686; Q96CV9-2:OPTN; NbExp=2; IntAct=EBI-524753, EBI-9091423; Q08499-8:PDE4D; NbExp=2; IntAct=EBI-524753, EBI-9090666; O15530-4:PDPK1; NbExp=3; IntAct=EBI-524753, EBI-9087775; P27986-2:PIK3R1; NbExp=2; IntAct=EBI-524753, EBI-9090282; Q9UF11-4:PLEKHB1; NbExp=4; IntAct=EBI-524753, EBI-9089825; Q16537:PPP2R5E; NbExp=2; IntAct=EBI-524753, EBI-968374; Q96DA2:RAB39B; NbExp=3; IntAct=EBI-524753, EBI-9089467; Q15047-2:SETDB1; NbExp=3; IntAct=EBI-524753, EBI-9090795; Q8IVB4:SLC9A9; NbExp=2; IntAct=EBI-524753, EBI-9092184; O00161:SNAP23; NbExp=4; IntAct=EBI-524753, EBI-745000; P60880:SNAP25; NbExp=3; IntAct=EBI-524753, EBI-524785; Q7Z699:SPRED1; NbExp=3; IntAct=EBI-524753, EBI-5235340; Q7Z698:SPRED2; NbExp=3; IntAct=EBI-524753, EBI-7082156; Q9C004:SPRY4; NbExp=2; IntAct=EBI-524753, EBI-354861; Q8NFA0:USP32; NbExp=2; IntAct=EBI-524753, EBI-2511075; Q9Y6W5:WASF2; NbExp=2; IntAct=EBI-524753, EBI-4290615;
MiscellaneousThe early and prominent pathology of HD is observed in the medium spiny neurons that project into the globus.
PtmAutopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport.
Sequence CautionSequence=AAF28972.1; Type=Frameshift; Positions=183, 191; Evidence= ; Sequence=AAH30990.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAA76790.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAC77366.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAC77388.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
SimilarityContains 1 DHHC-type zinc finger.
SimilarityContains 5 ANK repeats. {ECO
Subcellular LocationGolgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.
SubunitInteracts (via ANK repeats) with HD. This interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.
Tissue SpecificityExpressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes.