LMPD Database

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LMP000328

UniProt Annotations

Entry Information
Gene Namesterol carrier protein 2, liver
Protein EntryNLTP_MOUSE
UniProt IDP32020
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative initiation; Named isoforms=2; Name=SCPx; IsoId=P32020-1; Sequence=Displayed; Name=SCP2; IsoId=P32020-2; Sequence=VSP_018895; Note=Mitochondrial precursor. Contains a mitochondrial transit peptide at positions 405-424 (Potential). {ECO:0000305};
Catalytic Activity3-alpha,7-alpha,12-alpha-trihydroxy-5-beta- cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha- trihydroxy-24-oxo-5-beta-cholestanoyl-CoA.
FunctionMediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
SimilarityContains 1 SCP2 domain. {ECO:0000305}.
SimilarityIn the N-terminal section; belongs to the thiolase family. {ECO:0000305}.
Subcellular LocationCytoplasm. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues.
Subcellular LocationIsoform SCP2: Mitochondrion.
Subcellular LocationIsoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import. {ECO:0000250}.
SubunitInteracts with PEX5. {ECO:0000250}.
Tissue SpecificityPresent at low levels in all tissues examined but expressed predominantly in the liver.