LMPD Database

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LMP000295

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IB, pancreas
Protein EntryPA21B_MOUSE
UniProt IDQ9Z0Y2
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
PtmActivated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically (By similarity). {ECO:0000250}.
SimilarityBelongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular LocationSecreted. Note=secreted from pancreatic acinar cells in its inactive form. {ECO:0000250}.
SubunitMonomer or homodimer. The inactive pro-form is a homotrimer (By similarity). {ECO:0000250}.