LMPD Database

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LMP000287

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 26, subfamily b, polypeptide 1
Protein EntryCP26B_MOUSE
UniProt IDQ811W2
SpeciesMouse
Comments
Comment typeDescription
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Developmental StageIn the embryonic male gonad, expressed in somatic cells as early as E11.5 and persist throughout development. Expression is detected in peritubular myoepithelial cells in the postnatal testis, while expression is absent in developing and adult ovaries. {ECO:0000269|PubMed:16461896, ECO:0000269|PubMed:16574820}.
Disruption PhenotypeGerm cells enter meiosis precociously in embryonic testes, due to strong-up-regulation of Stra8. {ECO:0000269|PubMed:16574820}.
FunctionInvolved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. {ECO:0000269|PubMed:16461896, ECO:0000269|PubMed:16574820, ECO:0000269|PubMed:19838304, ECO:0000269|PubMed:22019272}.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.