LMPD Database

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LMP000278

UniProt Annotations

Entry Information
Gene NameNAD(P)H dehydrogenase, quinone 2
Protein EntryNQO2_MOUSE
UniProt IDQ9JI75
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity1-(beta-D-ribofuranosyl)-1,4- dihydronicotinamide + a quinone = 1-(beta-D- ribofuranosyl)nicotinamide + a hydroquinone.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionThe enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
MiscellaneousUses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.
SimilarityBelongs to the NAD(P)H dehydrogenase (quinone) family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.