LMPD Database

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LMP000259

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 11, subfamily A, polypeptide 1
Protein EntryCP11A_HUMAN
UniProt IDP05108
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P05108-1; Sequence=Displayed; Name=2; IsoId=P05108-2; Sequence=VSP_045695; Note=No experimental confirmation available.;
Catalytic ActivityCholesterol + 6 reduced adrenodoxin + 3 O(2) + 6 H(+) = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H(2)O.
CofactorName=heme; Xref=ChEBI
DiseaseAdrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) [MIM
FunctionCatalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
InductionBy 8-bromo cyclic AMP.
PathwayLipid metabolism; C21-steroid hormone metabolism.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationMitochondrion membrane.
SubunitInteracts with FDX1/adrenodoxin.