LMPD Database

LMP000206

Gene Information

Entrez Gene ID	3156
Gene Name	3-hydroxy-3-methylglutaryl-CoA reductase
Gene Symbol	HMGCR
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005783	IDA:UniProtKB	C	endoplasmic reticulum
GO:0005789	TAS:UniProtKB	C	endoplasmic reticulum membrane
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005778	IDA:UniProtKB	C	peroxisomal membrane
GO:0050662	IDA:UniProtKB	F	coenzyme binding
GO:0042282	IDA:UniProtKB	F	hydroxymethylglutaryl-CoA reductase activity
GO:0004420	IEA:UniProtKB-EC	F	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0070402	IDA:UniProtKB	F	NADPH binding
GO:0007568	IEA:Ensembl	P	aging
GO:0044255	TAS:Reactome	P	cellular lipid metabolic process
GO:0006695	TAS:Reactome	P	cholesterol biosynthetic process
GO:0015936	IEA:InterPro	P	coenzyme A metabolic process
GO:0008299	IEA:Ensembl	P	isoprenoid biosynthetic process
GO:0045445	IEA:Ensembl	P	myoblast differentiation
GO:0061179	IEA:Ensembl	P	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043407	IEA:Ensembl	P	negative regulation of MAP kinase activity
GO:0010664	IEA:Ensembl	P	negative regulation of striated muscle cell apoptotic process
GO:0045908	IEA:Ensembl	P	negative regulation of vasodilation
GO:0061045	IEA:Ensembl	P	negative regulation of wound healing
GO:0010666	IEA:Ensembl	P	positive regulation of cardiac muscle cell apoptotic process
GO:0070374	IEA:Ensembl	P	positive regulation of ERK1 and ERK2 cascade
GO:0048643	IEA:Ensembl	P	positive regulation of skeletal muscle tissue development
GO:0048661	IEA:Ensembl	P	positive regulation of smooth muscle cell proliferation
GO:0032874	IEA:Ensembl	P	positive regulation of stress-activated MAPK cascade
GO:0051262	IDA:UniProtKB	P	protein tetramerization
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0007584	IEA:Ensembl	P	response to nutrient
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0006743	IEA:Ensembl	P	ubiquinone metabolic process
GO:0008542	IEA:Ensembl	P	visual learning

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04152	AMPK signaling pathway