LMPD Database

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LMP000202

UniProt Annotations

Entry Information
Gene Namemyo-inositol 1-phosphate synthase A1
Protein EntryINO1_MOUSE
UniProt IDQ9JHU9
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityD-glucose 6-phosphate = 1D-myo-inositol 3- phosphate.
CofactorName=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
FunctionKey enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). {ECO:0000250}.
PathwayPolyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 1/2.
SimilarityBelongs to the myo-inositol 1-phosphate synthase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
Tissue SpecificityIn testis, it is expressed in Sertoli cells. Highly expressed in 2 types of germ cells, pachytene spermatocytes and round spermatids. {ECO:0000269|PubMed:14613899}.