LMPD Database

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LMP000183

UniProt Annotations

Entry Information
Gene Nameretinoid X receptor, beta
Protein EntryRXRB_HUMAN
UniProt IDQ5STP9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P28702-1; Sequence=Displayed; Name=2; IsoId=P28702-3; Sequence=VSP_045587;
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA).
InteractionQ00975:CACNA1B; NbExp=3; IntAct=EBI-748576, EBI-1055161;
Sequence CautionSequence=BAD92481.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
SimilarityBelongs to the nuclear hormone receptor family. NR2 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus.
SubunitHomodimer (By similarity). Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. {ECO
Tissue SpecificityExpressed in a variety of tumor cell lines.