LMPD Database

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LMP000150

UniProt Annotations

Entry Information
Gene Namepatatin-like phospholipase domain containing 8
Protein EntryPLPL8_HUMAN
UniProt IDQ9NP80
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NP80-1; Sequence=Displayed; Name=2; IsoId=Q9NP80-2; Sequence=VSP_028005; Note=No experimental confirmation available.; Name=3; IsoId=Q9NP80-3; Sequence=VSP_045594; Note=No experimental confirmation available.;
Biophysicochemical PropertiespH dependence: Optimum pH is 8.0.;
Catalytic Activity2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Enzyme RegulationInhibited by E-6-bromomethylene-3-1- naphthalenyl-2H-tetrahydropyran-2-one (BEL).
FunctionCalcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. {ECO
Sequence CautionSequence=AAF67630.1; Type=Erroneous initiation; Evidence= ; Sequence=BAA92090.1; Type=Erroneous initiation; Evidence= ; Sequence=EAL24384.1; Type=Erroneous gene model prediction; Evidence= ;
SimilarityContains 1 patatin domain.
Subcellular LocationEndoplasmic reticulum membrane {ECO
Tissue SpecificityExpressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart. {ECO