LMPD Database

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LMP000144

UniProt Annotations

Entry Information
Gene Nameapolipoprotein C-I
Protein EntryAPOC1_MOUSE
UniProt IDP34928
SpeciesMouse
Comments
Comment typeDescription
FunctionInhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein (By similarity). Binds free fatty acids and reduces their intracellular esterification. {ECO:0000250|UniProtKB:P02654, ECO:0000250|UniProtKB:P33047, ECO:0000269|PubMed:17339654}.
Mass SpectrometryMass=6825.6; Mass_error=0.495; Method=Electrospray; Range=29-88; Note=Strain C57BL/6. Without methionine sulfoxide.; Evidence={ECO:0000269|PubMed:16876491};
Mass SpectrometryMass=6993; Mass_error=0.707; Method=Electrospray; Range=27-88; Note=Strain C57BL/6. Without methionine sulfoxide.; Evidence={ECO:0000269|PubMed:16876491};
SimilarityBelongs to the apolipoprotein C1 family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000250|UniProtKB:P02654}.
Tissue SpecificityAdult and fetal liver. {ECO:0000269|PubMed:8276416}.