LMPD Database

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LMP000135

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase 8 family, member A1
Protein EntryAL8A1_MOUSE
UniProt IDQ8BH00
SpeciesMouse
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=2.3 uM for 9-cis-retinal {ECO:0000269|PubMed:12519776}; Vmax=3.4 nmol/min/mg enzyme {ECO:0000269|PubMed:12519776}; Note=Activity was measured with total soluble protein.;
FunctionConverts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has a preference for NAD, but shows considerable activity with NADP (in vitro) (By similarity). {ECO:0000250}.
SimilarityBelongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12519776}.
Tissue SpecificityDetected in hepatocytes and in proximal and distal convoluted tubules in kidney cortex (at protein level). Highly expressed in adult liver and in kidney cortex. First detected in embryonic liver after 15 days of development. {ECO:0000269|PubMed:12519776}.