LMPD Database

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LMP000122

UniProt Annotations

Entry Information
Gene Namefatty acid desaturase 2
Protein EntryFADS2_MOUSE
UniProt IDQ9Z0R9
SpeciesMouse
Comments
Comment typeDescription
Developmental StageFound in 13-day-old embryo heart.
DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding.
FunctionComponent of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions (By similarity). {ECO:0000250}.
InductionInduced by dietary PUFA-deficient diet. Induced by a fat-free diet and by a diet containing triolein (18:1n-9) as the only fat source. Down-regulated in liver by dietary PUFA. {ECO:0000269|PubMed:11792729, ECO:0000269|PubMed:9867867}.
PathwayLipid metabolism; polyunsaturated fatty acid biosynthesis.
SimilarityBelongs to the fatty acid desaturase family. {ECO:0000305}.
SimilarityContains 1 cytochrome b5 heme-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00279}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityHighly expressed in the adrenal gland, liver, brain, and testis, tissues where lipogenesis and steroidogenesis are active. Also detected in lung, heart, and skeletal muscle. {ECO:0000269|PubMed:11792729, ECO:0000269|PubMed:9867867}.