LMPD Database

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LMP000115

UniProt Annotations

Entry Information
Gene Namearachidonate lipoxygenase, epidermal
Protein EntryLX12E_MOUSE
UniProt IDP55249
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityArachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)- 12-hydroperoxyicosa-5,8,10,14-tetraenoate.
CautionWas originally thought to be an arachidonate 8- lipoxygenase and was called LOX8. {ECO:0000305}.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000255|PROSITE-ProRule:PRU00726}; Note=Binds 1 Fe cation per subunit. {ECO:0000255|PROSITE- ProRule:PRU00726};
FunctionNon-heme iron-containing dioxygenase that probably catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. May preferentially convert arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE. {ECO:0000269|PubMed:8798535, ECO:0000269|PubMed:9037187}.
PathwayLipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.
SimilarityBelongs to the lipoxygenase family. {ECO:0000305}.
SimilarityContains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
SimilarityContains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular LocationCytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}.
Tissue SpecificityExpressed in epidermis. {ECO:0000269|PubMed:8798535}.