LMPD Database

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LMP000093

UniProt Annotations

Entry Information
Gene Namesterol O-acyltransferase 1
Protein EntrySOAT1_MOUSE
UniProt IDQ61263
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + cholesterol = CoA + cholesterol ester.
FunctionCatalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption.
SimilarityBelongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000269|PubMed:11071899}.
SubunitMay form homo- or heterodimers. Interacts with UBIAD1 (By similarity). {ECO:0000250}.