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LMPD Database

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LMP000091

UniProt Annotations

Entry Information

Gene Name	low-density lipoprotein receptor-related protein 10
Protein Entry	LRP10_MOUSE
UniProt ID	Q7TQH7
Species	Mouse

Comments

Comment type	Description
Function	Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver. {ECO:0000269\|PubMed:11123907}.
Sequence Caution	Sequence=AAH11058.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Belongs to the LDLR family. {ECO:0000305}.
Similarity	Contains 2 CUB domains. {ECO:0000255\|PROSITE- ProRule:PRU00059}.
Similarity	Contains 4 LDL-receptor class A domains. {ECO:0000255\|PROSITE-ProRule:PRU00124}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Membrane, coated pit {ECO:0000250}.
Tissue Specificity	Highly expressed in heart, lung, liver and liver. Expressed at low level in brain and spleen. Weakly or not expressed in testis and skeletal muscle. In liver, it is expressed in hepatocytes and at higher level in sinusoidal lining. In the kidney, it is expressed in peritubular capillaries. In brain, it is expressed in the epithelium of the choroid plexus ependymal cells of the third ventricle pia matter, and to lesser extent in hippocampal fields CA2 and CA3. {ECO:0000269\|PubMed:11123907}.