LMPD Database

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LMP000087

UniProt Annotations

Entry Information
Gene Namepiccolo (presynaptic cytomatrix protein)
Protein EntryQ9QYX7_MOUSE
UniProt IDQ9QYX7
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=L; IsoId=Q9QYX7-1; Sequence=Displayed; Name=2; Synonyms=S; IsoId=Q9QYX7-2; Sequence=VSP_003928, VSP_003929;
DomainC2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change.
FunctionMay act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.
Sequence CautionSequence=BAC53723.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Several sequence problems.; Evidence= ; Sequence=BAC53724.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Several sequence problems.; Evidence= ; Sequence=CAB60731.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence= ; Sequence=CAB60732.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence= ;
SimilarityContains 1 PDZ (DHR) domain. {ECO:0000255|PROSITE- ProRule:PRU00143}.
SimilarityContains 2 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular LocationCell junction, synapse . Note=Concentrated at the presynaptic side of synaptic junctions.
SubunitInteracts with RABAC1/PRA1, RIMS2 and profilin.
Tissue SpecificityHighly expressed in brain. Moderately expressed in pituitary gland and pancreatic islets. Low levels found in stomach. {ECO:0000269|PubMed:10508862, ECO:0000269|PubMed:12401793}.