LMPD Database

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LMP000071

UniProt Annotations

Entry Information
Gene Namedehydrogenase/reductase (SDR family) member 9
Protein EntryDHRS9_HUMAN
UniProt IDQ9BPW9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BPW9-1; Sequence=Displayed; Name=2; Synonyms=Retinol dehydrogenase homolog isoform-2; IsoId=Q9BPW9-2; Sequence=VSP_015875; Note=No experimental confirmation available.; Name=3; Synonyms=Retinol dehydrogenase homolog isoform-1; IsoId=Q9BPW9-3; Sequence=VSP_015876; Note=No experimental confirmation available.; Name=4; IsoId=Q9BPW9-4; Sequence=VSP_054357; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=9 uM for NADH ; KM=72 uM for NAD ; KM=5 uM for allopregnanolone ; KM=7.5 uM for 3-alpha-androstanediol ; KM=24 uM for androsterone ; KM=12 uM for dihydrotestosterone ;
Function3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. {ECO
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular LocationMicrosome membrane {ECO
SubunitHomotetramer.
Tissue SpecificityHighly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node. {ECO