LMPD Database

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LMP000064

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group V
Protein EntryPA2G5_MOUSE
UniProt IDP97391
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes L- alpha-palmitoyl-2-oleoyl phosphatidylcholine more efficiently than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1- palmitoyl-2-arachidonyl phosphatidylethanolamine or L-alpha-1- stearoyl-2-arachidonyl phosphatidylinositol (By similarity). {ECO:0000250}.
PtmThis enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.
SimilarityBelongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000269|PubMed:10531350}. Membrane {ECO:0000269|PubMed:10531350}. Note=Also associated with various membranous organelles including the Golgi apparatus, nuclear envelope, and plasma membrane.