LMPD Database

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LMP000024

UniProt Annotations

Entry Information
Gene Nameflotillin 1
Protein EntryFLOT1_MOUSE
UniProt IDO08917
SpeciesMouse
Comments
Comment typeDescription
FunctionMay act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
MiscellaneousExpression increases at least 10-fold as 3T3-L1 cells differentiate into adipocytes.
SimilarityBelongs to the band 7/mec-2 family. Flotillin subfamily. {ECO:0000305}.
Subcellular LocationCell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Melanosome {ECO:0000250}. Endosome {ECO:0000250}. Note=Membrane-associated protein of caveolae.
SubunitHeterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECM29 (By similarity). {ECO:0000250}.
Tissue SpecificityHigh expression in brain, white adipose tissue, heart muscle, skeletal muscle and lung. Low expression in spleen, liver and testis.