LMPD Database

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LMP000022

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 3
Protein EntryDHB3_HUMAN
UniProt IDP37058
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P37058-1; Sequence=Displayed; Name=2; IsoId=P37058-2; Sequence=VSP_056640; Note=No experimental confirmation available.;
Catalytic ActivityTestosterone + NADP(+) = androst-4-ene-3,17- dione + NADPH.
DiseaseMale pseudohermaphrodism with gynecomastia (MPH) [MIM
FunctionFavors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.
PathwayHormone biosynthesis; testosterone biosynthesis.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
Tissue SpecificityTestis.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hsd17b3/";