LMPD Database

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LMP000007

UniProt Annotations

Entry Information
Gene NameST3 beta-galactoside alpha-2,3-sialyltransferase 5
Protein EntrySIAT9_MOUSE
UniProt IDO88829
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88829-1; Sequence=Displayed; Name=2; IsoId=O88829-2; Sequence=VSP_033689;
Catalytic ActivityCMP-N-acetylneuraminate + beta-D-galactosyl- (1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N- acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide.
Disruption PhenotypeMice are viable and fertile, and do not show any obvious abnormality apart from an increased sensitivity to insulin. {ECO:0000269|PubMed:12629211}.
FunctionCatalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide). {ECO:0000269|PubMed:12629211}.
Sequence CautionSequence=AAF66147.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA33491.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA76467.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB28571.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE34763.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA75235.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA75236.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC79655.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the glycosyltransferase 29 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=ST3Gal V; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_646";