Lipidomics update - April, 2018
The lipidomics update provides an overview of developments in lipid research. Each month we offer a fresh collection of research, news and events for the specialist and the interested non-specialist alike.
LIPID MAPS® highlights
LIPID MAPS Proteome Database (LMPD) - The LIPID MAPS Proteome Database (LMPD) of lipid-related genes and proteins contains data for over 8,500 genes and over 12,500 proteins from Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Caenorhabditis elegans, Escherichia coli, Macaca mulata, Drosophila melanogaster, Arabidopsis thaliana and Danio rerio.
Lipid of the month
Leukotriene B4 (5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid) is a pro-inflammatory eicosanoid mediator synthesised in myeloid cells from arachidonic acid. Synthesis is catalysed by 5-lipoxygenase and leukotriene A4 hydrolase and is increased by inflammatory mediators including endotoxin, complement fragments, tumor necrosis factor and interleukins. Leukotriene B4 is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue. In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosomal enzymes by these cells.
Events calendar
EMBO WORKSHOP, "Glycosylation in the Golgi complex"
October 24 -28, 2016
Biophysical Society 61st Annual Meeting
February 11 - 15, 2017
Research library
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The discovery and early structural studies of arachidonic acid
J Lipid Res(2016)
The Journal of Lipid Research, 57, 1126-1132. DOI: 10.1194/jlr.R068072
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Quantitative profiling of the endonuclear glycerophospholipidome of murine embryonic fibroblasts
J. Lipid Res. 2016 57:(8) 1492-1506. First Published on June 2, 2016, doi:10.1194/jlr.M068734