Microarray analysis of thioglycolate-elicited macrophage cells treated with Kdo₂-lipid A (KLA) and compactin

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Heatmap of compactin/KLA time course data for lipid category ST (Ratio to control values)

Gene Time course graph Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr Ch25h KLA  Compactin  Compactin+KLA cholesterol 25-hydroxylase (Ch25h), mRNA [NM_009890] KLA 1.20 3.70 18.30 82.24 109.92 90.48 34.38   Compactin 1.01 0.97 0.98 1.13 1.03 1.03 1.02   Compactin+KLA 1.05 3.15 15.69 80.00 90.21 64.75 13.43 Cyp51 KLA  Compactin  Compactin+KLA cytochrome P450, family 51 (Cyp51), mRNA [NM_020010] KLA 1.00 1.25 1.15 1.23 0.91 0.64 0.59   Compactin 0.97 1.02 1.08 1.09 1.04 1.11 1.04   Compactin+KLA 0.95 1.16 1.30 1.46 1.14 0.71 0.71 Dhcr24 KLA  Compactin  Compactin+KLA 24-dehydrocholesterol reductase (Dhcr24), mRNA [NM_053272] KLA 0.85 1.00 1.15 0.88 0.66 0.51 0.43   Compactin 0.98 1.12 1.03 1.07 1.14 1.23 1.07   Compactin+KLA 0.87 1.07 1.25 1.02 0.78 0.60 0.55 Dhcr7 KLA  Compactin  Compactin+KLA 7-dehydrocholesterol reductase (Dhcr7), mRNA [NM_007856] KLA 0.96 0.91 0.78 0.37 0.26 0.33 0.57   Compactin 1.05 1.02 1.07 1.07 1.02 1.08 1.08   Compactin+KLA 0.96 0.94 0.76 0.39 0.28 0.42 0.65 Ebp KLA  Compactin  Compactin+KLA phenylalkylamine Ca2 antagonist (emopamil) binding protein (Ebp), mRNA [NM_007898] KLA 1.05 0.97 0.81 0.70 0.60 0.63 0.80   Compactin 1.02 1.06 1.04 0.98 1.07 1.05 1.06   Compactin+KLA 1.02 0.87 0.92 0.74 0.60 0.64 0.89 Fdft1 KLA  Compactin  Compactin+KLA farnesyl diphosphate farnesyl transferase 1 (Fdft1), mRNA [NM_010191] KLA 1.02 1.10 0.95 1.04 0.84 0.70 0.67   Compactin 1.00 1.06 1.05 1.04 1.11 1.16 1.08   Compactin+KLA 1.04 1.03 1.01 1.10 1.00 0.76 0.75 Fdps KLA  Compactin  Compactin+KLA 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030492I17 product:farnesyl diphosphate synthetase, full insert sequence. [AK077979] KLA 0.71 0.76 0.78 0.83 0.61 0.79 0.78   Compactin 1.09 1.29 1.22 1.16 1.11 1.05 0.97   Compactin+KLA 0.80 0.85 0.78 0.95 0.62 0.75 0.86 Fdps KLA  Compactin  Compactin+KLA farnesyl diphosphate synthetase (Fdps), mRNA [NM_134469] KLA 1.07 0.94 1.01 1.10 0.87 0.69 0.83   Compactin 1.01 1.04 1.09 1.23 1.20 1.36 1.02   Compactin+KLA 0.91 1.19 1.32 0.99 1.01 1.01 1.22 Ggps1 KLA  Compactin  Compactin+KLA adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330064P13 product:geranylgeranyl diphosphate synthase 1, full insert sequence [AK138564] KLA 1.09 0.86 0.88 0.99 1.14 1.11 1.16   Compactin 1.00 0.95 1.00 0.99 0.99 1.05 1.13   Compactin+KLA 0.97 0.82 0.83 1.01 1.23 1.03 1.09 Ggps1 KLA  Compactin  Compactin+KLA geranylgeranyl diphosphate synthase 1 (Ggps1), mRNA [NM_010282] KLA 1.06 0.94 1.10 1.34 1.55 1.59 1.85   Compactin 1.00 0.96 1.10 1.03 1.01 1.04 1.11   Compactin+KLA 1.05 0.90 1.15 1.33 1.65 1.56 1.72 Hmgcr KLA  Compactin  Compactin+KLA 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] KLA 1.06 1.48 1.44 2.07 1.64 1.22 0.96   Compactin 0.99 0.97 1.12 1.05 1.10 1.10 1.02   Compactin+KLA 0.97 1.49 1.57 2.26 1.88 1.28 1.06 Hmgcs2 KLA  Compactin  Compactin+KLA 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2), nuclear gene encoding mitochondrial protein, mRNA [NM_008256] KLA 1.10 0.98 1.06 1.07 1.00 1.00 1.05   Compactin 1.03 1.11 0.97 1.00 1.07 1.01 0.93   Compactin+KLA 1.00 0.96 0.97 1.01 1.03 0.97 0.95 Hsd17b7 KLA  Compactin  Compactin+KLA hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7), mRNA [NM_010476] KLA 1.00 1.01 1.00 1.19 1.46 1.15 1.02   Compactin 1.01 1.01 1.07 1.10 1.07 1.12 1.09   Compactin+KLA 0.87 0.98 1.08 1.31 1.86 1.30 1.19 Idi1 KLA  Compactin  Compactin+KLA isopentenyl-diphosphate delta isomerase (Idi1), transcript variant 2, mRNA [NM_177960] KLA 1.08 1.20 1.29 1.15 0.83 0.56 0.64   Compactin 0.98 0.90 1.04 1.04 1.15 1.08 1.08   Compactin+KLA 1.00 1.30 1.44 1.32 1.06 0.65 0.69 Lss KLA  Compactin  Compactin+KLA adult male brain UNDEFINED_CELL_LINE cDNA, RIKEN full-length enriched library, clone:M5C1106O04 product:lanosterol synthase, full insert sequence [AK147680] KLA 1.00 0.73 0.60 0.51 0.50 0.53 0.73   Compactin 0.97 0.98 1.08 0.99 1.13 1.09 1.03   Compactin+KLA 1.08 0.79 0.58 0.57 0.57 0.65 0.77 Lss KLA  Compactin  Compactin+KLA lanosterol synthase (Lss), mRNA [NM_146006] KLA 0.93 1.00 0.86 0.84 0.84 0.88 1.11   Compactin 0.97 0.98 1.33 1.09 1.04 1.11 1.12   Compactin+KLA 1.02 0.98 0.89 0.93 1.11 1.09 1.21 Mvd KLA  Compactin  Compactin+KLA mevalonate (diphospho) decarboxylase (Mvd), mRNA [NM_138656] KLA 0.93 0.81 0.52 0.45 0.62 0.72 1.00   Compactin 1.06 1.05 1.08 1.23 1.20 1.33 1.16   Compactin+KLA 1.04 0.89 0.53 0.56 0.90 0.90 1.32 Mvk KLA  Compactin  Compactin+KLA mevalonate kinase (Mvk), mRNA [NM_023556] KLA 1.03 1.08 1.04 0.81 0.86 0.89 1.09   Compactin 1.07 1.14 1.06 1.12 1.07 1.17 1.10   Compactin+KLA 1.06 1.04 0.92 0.90 1.05 1.03 1.21 Nsdhl KLA  Compactin  Compactin+KLA activated spleen cDNA, RIKEN full-length enriched library, clone:F830111P16 product:unclassifiable, full insert sequence [AK156993] KLA 1.01 0.89 0.83 0.82 0.83 0.88 0.84   Compactin 0.98 1.03 0.96 0.86 1.03 0.97 0.87   Compactin+KLA 0.96 0.92 0.83 0.80 0.80 0.90 0.91 Nsdhl KLA  Compactin  Compactin+KLA NAD(P) dependent steroid dehydrogenase-like (Nsdhl), mRNA [NM_010941] KLA 1.00 0.96 1.06 0.94 0.83 0.85 0.99   Compactin 1.03 0.94 1.16 1.10 0.99 1.07 1.12   Compactin+KLA 1.06 0.98 1.03 0.93 1.09 0.91 1.06 Pmvk KLA  Compactin  Compactin+KLA phosphomevalonate kinase (Pmvk), mRNA [NM_026784] KLA 1.02 0.89 0.90 0.82 0.88 0.69 0.87   Compactin 1.05 0.95 1.03 1.04 1.07 1.15 1.15   Compactin+KLA 0.95 0.93 0.93 0.96 1.06 0.84 1.04 Sc4mol KLA  Compactin  Compactin+KLA sterol-C4-methyl oxidase-like (Sc4mol), mRNA [NM_025436] KLA 1.01 0.90 0.67 0.59 0.58 0.44 0.47   Compactin 0.99 0.91 1.04 1.07 1.06 1.05 1.09   Compactin+KLA 0.99 0.84 0.80 0.67 0.79 0.54 0.58 Sc5d KLA  Compactin  Compactin+KLA 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830073K23 product:unclassifiable, full insert sequence [AK080673] KLA 0.93 0.71 0.52 0.41 0.26 0.26 0.29   Compactin 1.01 0.93 1.02 1.00 0.98 1.06 1.03   Compactin+KLA 1.04 0.78 0.53 0.41 0.28 0.28 0.31 Sc5d KLA  Compactin  Compactin+KLA sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) (Sc5d), mRNA [NM_172769] KLA 1.06 0.92 0.97 0.85 0.62 0.42 0.49   Compactin 0.99 0.91 1.09 1.04 1.10 1.08 1.08   Compactin+KLA 0.99 0.95 1.10 0.99 0.76 0.50 0.54 Soat1 KLA  Compactin  Compactin+KLA sterol O-acyltransferase 1 (Soat1), mRNA [NM_009230] KLA 0.95 0.90 0.72 0.47 0.34 0.43 0.48   Compactin 0.98 1.04 0.99 0.95 1.05 1.06 1.04   Compactin+KLA 0.95 0.93 0.77 0.45 0.33 0.45 0.58 Soat2 KLA  Compactin  Compactin+KLA sterol O-acyltransferase 2 (Soat2), mRNA [NM_146064] KLA 0.93 1.01 1.02 0.98 1.05 1.07 1.31   Compactin 1.03 0.95 1.03 1.06 1.05 1.12 1.10   Compactin+KLA 1.02 1.08 0.98 1.08 1.09 1.17 1.39 Sqle KLA  Compactin  Compactin+KLA squalene epoxidase (Sqle), mRNA [NM_009270] KLA 0.97 0.97 0.82 0.57 0.64 0.50 0.55   Compactin 1.02 0.94 1.00 1.14 1.15 1.17 1.07   Compactin+KLA 0.98 0.94 0.86 0.68 0.96 0.63 0.66 Tm7sf2 KLA  Compactin  Compactin+KLA transmembrane 7 superfamily member 2 (Tm7sf2), mRNA [NM_028454] KLA 0.89 1.00 0.94 0.77 0.53 0.43 0.47   Compactin 1.00 1.05 1.06 1.03 1.06 1.15 1.09   Compactin+KLA 1.01 0.91 0.91 0.79 0.56 0.47 0.61