Microarray analysis of thioglycolate-elicited macrophage cells treated with Kdo₂-lipid A (KLA) and compactin

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Heatmap of compactin/KLA time course data for lipid category SP (Ratio to control values)

Gene Time course graph Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr Asah1 KLA  Compactin  Compactin+KLA N-acylsphingosine amidohydrolase 1 (Asah1), mRNA [NM_019734] KLA 1.10 1.01 0.90 0.66 0.54 0.58 0.72   Compactin 0.93 0.98 1.07 0.96 0.98 1.01 1.07   Compactin+KLA 1.04 0.99 0.91 0.63 0.58 0.60 0.72 Cerk KLA  Compactin  Compactin+KLA ceramide kinase (Cerk), mRNA [NM_145475] KLA 1.09 1.05 0.55 0.35 0.48 0.57 0.56   Compactin 1.01 1.10 1.11 1.04 1.05 1.07 1.05   Compactin+KLA 1.07 1.19 0.59 0.35 0.51 0.61 0.66 Degs1 KLA  Compactin  Compactin+KLA degenerative spermatocyte homolog 1 (Drosophila) (Degs1), mRNA [NM_007853] KLA 0.97 0.91 0.97 0.77 0.49 0.42 0.48   Compactin 0.90 1.05 0.96 0.96 1.00 1.00 0.90   Compactin+KLA 0.87 1.04 1.07 0.71 0.43 0.46 0.61 Degs2 KLA  Compactin  Compactin+KLA degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase (Degs2), mRNA [NM_027299] KLA 0.96 1.00 0.98 1.04 0.97 0.98 0.99   Compactin 0.97 1.04 0.99 1.04 0.97 1.05 1.01   Compactin+KLA 0.98 1.04 1.02 1.03 1.02 1.04 0.97 Kdsr KLA  Compactin  Compactin+KLA 3-ketodihydrosphingosine reductase (Kdsr), mRNA [NM_027534] KLA 1.06 0.92 0.72 0.35 0.38 0.43 0.55   Compactin 1.00 0.95 0.91 0.94 0.97 0.95 0.98   Compactin+KLA 1.04 0.93 0.69 0.36 0.38 0.44 0.56 Kdsr KLA  Compactin  Compactin+KLA 3-ketodihydrosphingosine reductase KLA 1.18 0.92 0.66 0.45 0.46 0.48 0.56   Compactin 1.12 1.00 0.98 0.95 0.88 0.92 1.04   Compactin+KLA 1.07 0.84 0.68 0.43 0.47 0.52 0.63 Lass2 KLA  Compactin  Compactin+KLA LAG1 homolog, ceramide synthase 2 (Lass2), mRNA [NM_029789] KLA 0.93 0.95 0.99 0.98 0.98 1.11 0.96   Compactin 1.00 0.99 1.00 1.04 0.98 0.98 0.98   Compactin+KLA 1.01 0.91 1.05 0.95 1.05 1.06 0.90 Lass4 KLA  Compactin  Compactin+KLA 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630036I10 product:longevity assurance homolog 4 (S. cerevisiae), full insert sequence. [AK036108] KLA 1.01 1.02 1.01 1.03 0.93 0.88 0.92   Compactin 1.00 0.95 1.10 1.08 1.03 1.04 0.97   Compactin+KLA 1.02 0.98 1.01 1.05 0.84 0.98 0.97 Lass4 KLA  Compactin  Compactin+KLA LAG1 homolog, ceramide synthase 4 (Lass4), mRNA [NM_026058] KLA 1.04 0.93 1.02 0.85 0.63 0.54 0.45   Compactin 1.07 0.95 0.94 1.04 0.97 1.04 1.05   Compactin+KLA 1.01 0.93 1.02 0.87 0.65 0.53 0.46 Lass5 KLA  Compactin  Compactin+KLA LAG1 homolog, ceramide synthase 5 (Lass5), mRNA [NM_028015] KLA 0.98 1.03 0.99 0.67 0.40 0.45 0.61   Compactin 1.04 0.96 1.00 0.94 0.95 0.98 0.93   Compactin+KLA 1.03 0.98 0.90 0.63 0.44 0.47 0.63 Lass6 KLA  Compactin  Compactin+KLA adult male colon cDNA, RIKEN full-length enriched library, clone:9030601N10 product:unclassifiable, full insert sequence [AK136463] KLA 1.06 0.84 1.48 3.63 2.38 1.53 1.35   Compactin 1.04 0.98 0.90 0.82 1.07 1.02 0.86   Compactin+KLA 0.95 1.02 1.87 2.68 1.82 1.66 1.51 Lass6 KLA  Compactin  Compactin+KLA LAG1 homolog, ceramide synthase 6 (Lass6), mRNA [NM_172856] KLA 1.06 1.64 2.96 7.50 7.56 6.59 3.62   Compactin 1.03 1.00 0.99 0.97 1.10 1.04 1.01   Compactin+KLA 1.04 1.56 2.83 7.79 7.97 5.53 3.14 Ppap2a KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase 2a (Ppap2a), transcript variant 2, mRNA [NM_008903] KLA 1.05 0.99 1.29 2.73 7.14 10.56 10.34   Compactin 1.01 0.94 1.07 0.97 0.84 0.88 0.61   Compactin+KLA 1.07 0.92 1.28 2.85 8.53 10.79 9.15 Ppap2b KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2B (Ppap2b), mRNA [NM_080555] KLA 1.00 1.26 1.81 2.73 2.01 2.04 1.36   Compactin 1.02 1.02 0.86 1.16 0.93 1.00 0.94   Compactin+KLA 1.06 1.12 1.57 2.54 1.86 1.85 1.18 Ppap2c KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2c KLA 0.96 0.88 0.98 0.85 0.55 0.41 0.53   Compactin 1.08 1.01 1.05 0.99 1.01 1.04 1.02   Compactin+KLA 1.03 0.87 0.95 0.85 0.61 0.43 0.61 Ppap2c KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2c (Ppap2c), mRNA [NM_015817] KLA 0.88 0.99 1.13 1.00 0.71 0.61 0.71   Compactin 1.07 1.06 1.14 1.06 0.93 1.03 1.14   Compactin+KLA 0.98 0.91 1.15 0.99 0.78 0.48 0.80 Sgms1 KLA  Compactin  Compactin+KLA sphingomyelin synthase 1 KLA 1.18 3.44 2.59 0.56 0.84 0.52 0.49   Compactin 1.07 0.90 1.09 0.98 0.98 1.09 1.04   Compactin+KLA 1.01 3.10 2.76 0.63 0.79 0.54 0.62 Sgms1 KLA  Compactin  Compactin+KLA sphingomyelin synthase 1 (Sgms1), mRNA [NM_144792] KLA 0.98 3.76 2.68 0.56 0.83 0.59 0.55   Compactin 0.88 1.40 1.10 1.23 1.12 1.17 1.04   Compactin+KLA 0.97 3.88 2.54 0.67 0.76 0.56 0.65 Sgpl1 KLA  Compactin  Compactin+KLA sphingosine phosphate lyase 1 (Sgpl1), mRNA [NM_009163] KLA 1.06 0.94 1.00 1.22 1.18 1.06 0.85   Compactin 1.10 0.97 1.06 0.97 0.99 1.04 0.94   Compactin+KLA 0.96 1.11 1.18 1.11 1.05 1.19 1.04 Smpd1 KLA  Compactin  Compactin+KLA sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1), mRNA [NM_011421] KLA 1.06 0.92 0.73 0.61 0.56 0.66 0.94   Compactin 1.17 1.35 1.02 1.14 1.12 1.24 1.10   Compactin+KLA 1.00 1.01 1.00 0.66 0.51 0.73 1.21 Sphk1 KLA  Compactin  Compactin+KLA sphingosine kinase 1 (Sphk1), transcript variant 2, mRNA [NM_025367] KLA 0.99 1.12 3.05 4.12 1.23 0.70 0.60   Compactin 1.02 1.05 1.16 1.05 1.08 1.01 1.09   Compactin+KLA 0.95 1.20 2.83 4.09 1.28 0.73 0.69 Sphk2 KLA  Compactin  Compactin+KLA sphingosine kinase 2 (Sphk2), transcript variant 2, mRNA [NM_020011] KLA 0.92 0.82 0.61 0.90 1.32 1.35 1.06   Compactin 0.98 1.07 1.00 0.97 0.96 1.05 0.99   Compactin+KLA 1.08 0.80 0.56 0.89 1.33 1.29 0.94 Sptlc1 KLA  Compactin  Compactin+KLA serine palmitoyltransferase, long chain base subunit 1 (Sptlc1), mRNA [NM_009269] KLA 0.98 0.95 1.14 1.19 0.98 0.97 0.99   Compactin 1.03 0.96 0.98 0.96 0.92 0.96 0.96   Compactin+KLA 1.02 0.93 1.04 1.09 1.06 0.93 0.98 Sptlc2 KLA  Compactin  Compactin+KLA serine palmitoyltransferase, long chain base subunit 2 (Sptlc2), mRNA [NM_011479] KLA 0.97 0.94 1.26 1.80 1.35 1.12 1.08   Compactin 0.99 0.94 0.98 0.96 1.03 1.05 1.07   Compactin+KLA 0.98 1.00 1.35 1.66 1.36 1.19 1.16 Ugcg KLA  Compactin  Compactin+KLA UDP-glucose ceramide glucosyltransferase, mRNA (cDNA clone MGC:59317 IMAGE:6512920), complete cds [BC050828] KLA 1.35 2.08 2.75 4.64 2.97 2.78 1.46   Compactin 1.22 1.20 0.91 0.94 1.23 1.25 1.03   Compactin+KLA 1.18 2.49 3.95 4.00 2.39 2.38 1.84 Ugcg KLA  Compactin  Compactin+KLA UDP-glucose ceramide glucosyltransferase (Ugcg), mRNA [NM_011673] KLA 1.07 2.52 3.04 4.22 2.74 2.33 1.67   Compactin 0.97 1.08 0.95 0.92 0.99 0.97 0.99   Compactin+KLA 1.08 2.16 2.96 3.90 2.50 2.03 1.65 Ugt8a KLA  Compactin  Compactin+KLA UDP galactosyltransferase 8A (Ugt8a), mRNA [NM_011674] KLA 0.95 0.97 0.95 1.09 1.06 0.99 0.98   Compactin 1.04 1.06 0.96 0.97 1.01 1.02 1.03   Compactin+KLA 0.94 0.97 1.01 0.96 0.99 1.01 0.98