Microarray analysis of thioglycolate-elicited macrophage cells treated with Kdo₂-lipid A (KLA) and compactin

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Heatmap of compactin/KLA time course data for lipid category GL,GP (Ratio to control values)

Gene Time course graph Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr Agpat6 KLA  Compactin  Compactin+KLA 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (Agpat6), mRNA [NM_018743] KLA 0.98 0.93 1.15 1.33 1.41 1.46 1.43   Compactin 1.03 0.99 0.97 1.03 0.97 1.00 1.00   Compactin+KLA 0.95 0.96 1.21 1.27 1.39 1.46 1.52 Cdipt KLA  Compactin  Compactin+KLA CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) (Cdipt), mRNA [NM_026638] KLA 0.92 0.99 1.00 0.98 0.93 1.02 1.04   Compactin 0.97 1.02 0.95 1.03 0.98 0.96 1.03   Compactin+KLA 1.03 0.93 0.94 0.97 0.96 0.96 0.99 Cds1 KLA  Compactin  Compactin+KLA CDP-diacylglycerol synthase 1 (Cds1), mRNA [NM_173370] KLA 0.94 1.10 1.48 2.85 2.01 1.32 1.16   Compactin 1.00 1.09 0.97 1.10 1.04 1.07 1.06   Compactin+KLA 0.99 1.06 1.43 2.98 2.01 1.32 1.24 Chkb KLA  Compactin  Compactin+KLA choline kinase beta (Chkb), mRNA [NM_007692] KLA 0.85 1.00 0.87 0.70 0.68 0.63 0.66   Compactin 0.93 1.19 0.99 1.05 0.96 0.94 0.95   Compactin+KLA 0.91 1.01 0.86 0.72 0.63 0.70 0.71 Chpt1 KLA  Compactin  Compactin+KLA choline phosphotransferase 1 (Chpt1), mRNA [NM_144807] KLA 1.06 0.89 1.01 1.08 1.25 1.27 1.60   Compactin 1.00 0.92 1.05 0.99 1.00 1.00 1.13   Compactin+KLA 0.95 0.89 1.00 1.05 1.35 1.32 1.67 Dgkz KLA  Compactin  Compactin+KLA diacylglycerol kinase zeta (Dgkz), mRNA [NM_138306] KLA 0.99 0.91 0.40 0.38 0.61 0.80 0.86   Compactin 1.02 1.10 1.09 1.07 1.03 1.02 0.98   Compactin+KLA 1.07 0.90 0.38 0.39 0.64 0.82 0.82 Etnk1 KLA  Compactin  Compactin+KLA gb|PREDICTED: Mus musculus ethanolamine kinase 1 (Etnk1), mRNA [XM_908334] KLA 0.99 1.03 1.41 4.35 3.51 2.96 1.96   Compactin 0.98 1.00 1.08 1.02 1.01 1.01 1.05   Compactin+KLA 1.00 1.01 1.45 4.23 3.67 2.62 1.68 Gpam KLA  Compactin  Compactin+KLA glycerol-3-phosphate acyltransferase, mitochondrial (Gpam), nuclear gene encoding mitochondrial protein, mRNA [NM_008149] KLA 1.03 1.02 0.96 1.08 0.99 1.01 1.08   Compactin 0.99 0.97 0.98 1.02 0.98 1.05 1.04   Compactin+KLA 1.06 1.11 1.04 1.10 1.01 1.12 1.10 Pcyt1a KLA  Compactin  Compactin+KLA 10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:B930020C23 product:phosphate cytidylyltransferase 1, choline, alpha isoform, full insert sequence [AK163685] KLA 1.00 0.83 0.51 0.65 0.36 0.37 0.34   Compactin 0.95 0.92 1.09 0.96 0.97 0.94 1.02   Compactin+KLA 1.02 0.86 0.50 0.57 0.39 0.37 0.37 Pcyt1a KLA  Compactin  Compactin+KLA phosphate cytidylyltransferase 1, choline, alpha isoform (Pcyt1a), mRNA [NM_009981] KLA 1.05 0.83 0.56 0.72 0.47 0.43 0.44   Compactin 1.01 0.97 1.10 0.97 0.94 0.95 1.03   Compactin+KLA 1.03 0.89 0.54 0.64 0.54 0.49 0.44 Pcyt2 KLA  Compactin  Compactin+KLA phosphate cytidylyltransferase 2, ethanolamine (Pcyt2), mRNA [NM_024229] KLA 0.96 0.97 0.78 0.65 0.57 0.57 0.62   Compactin 1.05 1.06 0.96 1.08 1.04 1.08 0.98   Compactin+KLA 1.04 0.97 0.74 0.75 0.67 0.65 0.65 Pemt KLA  Compactin  Compactin+KLA phosphatidylethanolamine N-methyltransferase (Pemt), nuclear gene encoding mitochondrial protein, mRNA [NM_008819] KLA 1.02 1.03 1.06 1.00 1.06 1.08 1.14   Compactin 1.08 1.04 1.00 1.05 1.01 1.10 1.17   Compactin+KLA 0.99 1.02 1.05 1.06 0.98 1.05 1.20 Pisd KLA  Compactin  Compactin+KLA phosphatidylserine decarboxylase (Pisd), mRNA [NM_177298] KLA 0.88 0.86 0.77 0.80 0.82 0.85 0.82   Compactin 0.99 1.06 1.02 1.01 0.93 0.86 0.84   Compactin+KLA 0.95 0.80 0.75 0.74 0.83 0.90 0.77 Pla2g1b KLA  Compactin  Compactin+KLA phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA 1.01 1.02 1.03 0.98 1.02 0.93 1.03   Compactin 1.02 0.97 0.98 0.92 1.04 1.06 0.99   Compactin+KLA 1.05 1.01 0.98 1.00 1.01 1.04 1.12 Pld1 KLA  Compactin  Compactin+KLA phospholipase D1 (Pld1), mRNA [NM_008875] KLA 1.06 1.02 0.83 0.85 0.75 0.83 1.06   Compactin 0.99 0.94 1.12 1.04 0.94 0.97 1.03   Compactin+KLA 1.08 1.06 0.86 0.77 0.83 0.93 1.09 Pnpla3 KLA  Compactin  Compactin+KLA patatin-like phospholipase domain containing 3 (Pnpla3), mRNA [NM_054088] KLA 0.99 0.96 1.04 1.01 1.01 0.98 1.04   Compactin 0.98 1.03 0.99 1.00 1.00 0.96 1.03   Compactin+KLA 1.06 0.99 1.00 0.98 0.97 0.96 1.01 Ppap2a KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase 2a (Ppap2a), transcript variant 2, mRNA [NM_008903] KLA 1.05 0.99 1.29 2.73 7.14 10.56 10.34   Compactin 1.01 0.94 1.07 0.97 0.84 0.88 0.61   Compactin+KLA 1.07 0.92 1.28 2.85 8.53 10.79 9.15 Ppap2b KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2B (Ppap2b), mRNA [NM_080555] KLA 1.00 1.26 1.81 2.73 2.01 2.04 1.36   Compactin 1.02 1.02 0.86 1.16 0.93 1.00 0.94   Compactin+KLA 1.06 1.12 1.57 2.54 1.86 1.85 1.18 Ppap2c KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2c KLA 0.96 0.88 0.98 0.85 0.55 0.41 0.53   Compactin 1.08 1.01 1.05 0.99 1.01 1.04 1.02   Compactin+KLA 1.03 0.87 0.95 0.85 0.61 0.43 0.61 Ppap2c KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2c (Ppap2c), mRNA [NM_015817] KLA 0.88 0.99 1.13 1.00 0.71 0.61 0.71   Compactin 1.07 1.06 1.14 1.06 0.93 1.03 1.14   Compactin+KLA 0.98 0.91 1.15 0.99 0.78 0.48 0.80 Ptdss1 KLA  Compactin  Compactin+KLA phosphatidylserine synthase 1 (Ptdss1), mRNA [NM_008959] KLA 0.97 0.89 1.05 0.97 0.88 0.97 0.94   Compactin 1.02 0.99 1.07 1.04 0.90 1.06 1.00   Compactin+KLA 1.00 0.85 0.95 0.99 0.95 0.98 0.93 Ptdss2 KLA  Compactin  Compactin+KLA phosphatidylserine synthase 2 (Ptdss2), mRNA [NM_013782] KLA 0.95 0.95 0.96 0.85 0.90 1.12 1.10   Compactin 1.02 1.02 1.13 1.10 0.93 0.96 1.11   Compactin+KLA 1.01 0.87 0.89 0.88 1.01 1.11 1.18