Microarray analysis of thioglycolate-elicited macrophage cells treated with Kdo₂-lipid A (KLA) and compactin

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Heatmap of compactin/KLA time course data for lipid category FC (Ratio to control values)

Gene Time course graph Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr Acaa1a KLA  Compactin  Compactin+KLA acetyl-Coenzyme A acyltransferase 1A (Acaa1a), mRNA [NM_130864] KLA 0.98 0.94 1.16 1.57 1.83 1.92 1.61   Compactin 0.99 1.06 0.98 0.99 0.95 1.01 1.03   Compactin+KLA 0.99 0.92 1.05 1.56 1.75 1.76 1.56 Acox1 KLA  Compactin  Compactin+KLA acyl-Coenzyme A oxidase 1, palmitoyl (Acox1), mRNA [NM_015729] KLA 1.03 0.98 0.81 0.70 0.59 0.65 0.78   Compactin 0.97 1.01 1.07 1.01 0.99 0.99 0.96   Compactin+KLA 1.02 0.91 0.90 0.71 0.60 0.66 0.85 Acox3 KLA  Compactin  Compactin+KLA acyl-Coenzyme A oxidase 3, pristanoyl KLA 0.89 0.80 0.78 0.40 0.27 0.26 0.45   Compactin 0.95 1.08 1.05 1.08 1.00 1.03 0.96   Compactin+KLA 0.95 1.05 0.89 0.38 0.22 0.31 0.59 Acox3 KLA  Compactin  Compactin+KLA acyl-Coenzyme A oxidase 3, pristanoyl (Acox3), mRNA [NM_030721] KLA 0.90 1.01 0.79 0.45 0.24 0.27 0.48   Compactin 1.02 1.03 0.91 1.09 0.93 0.94 0.99   Compactin+KLA 1.00 0.97 0.71 0.44 0.25 0.28 0.45 Elovl2 KLA  Compactin  Compactin+KLA elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), mRNA [NM_019423] KLA 1.02 0.98 0.92 1.14 1.26 1.15 1.04   Compactin 0.91 0.99 0.93 0.94 0.89 1.03 0.91   Compactin+KLA 0.99 0.98 1.08 1.12 1.33 1.08 1.07 Elovl5 KLA  Compactin  Compactin+KLA ELOVL family member 5, elongation of long chain fatty acids (yeast) (Elovl5), mRNA [NM_134255] KLA 1.09 0.94 0.86 0.49 0.35 0.49 0.67   Compactin 0.98 0.90 0.99 0.88 1.03 1.00 1.02   Compactin+KLA 1.05 0.92 0.85 0.47 0.41 0.50 0.65 Elovl6 KLA  Compactin  Compactin+KLA ELOVL family member 6, elongation of long chain fatty acids (yeast) KLA 1.14 0.82 0.76 0.71 0.47 0.45 0.58   Compactin 1.02 0.94 1.07 1.16 1.09 1.04 0.83   Compactin+KLA 1.08 1.03 0.88 0.63 0.47 0.45 0.55 Elovl6 KLA  Compactin  Compactin+KLA ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA [NM_130450] KLA 0.93 0.99 0.85 0.61 0.42 0.39 0.57   Compactin 0.95 0.98 1.13 1.10 1.01 0.98 0.86   Compactin+KLA 1.06 0.93 0.78 0.54 0.45 0.39 0.50 Fads1 KLA  Compactin  Compactin+KLA fatty acid desaturase 1 (Fads1), mRNA [NM_146094] KLA 0.96 0.93 0.67 0.35 0.27 0.43 0.67   Compactin 1.01 1.14 1.03 1.10 0.97 1.03 1.02   Compactin+KLA 0.99 0.85 0.68 0.36 0.30 0.48 0.74 Fads2 KLA  Compactin  Compactin+KLA fatty acid desaturase 2 (Fads2), mRNA [NM_019699] KLA 1.01 1.00 1.01 0.95 1.02 1.13 0.98   Compactin 0.99 1.05 1.02 1.05 1.00 1.05 0.87   Compactin+KLA 1.01 1.00 1.11 1.02 1.14 1.03 0.91 Fasn KLA  Compactin  Compactin+KLA fatty acid synthase (Fasn), mRNA [NM_007988] KLA 1.04 0.94 0.94 0.68 0.64 0.69 0.87   Compactin 1.01 0.97 0.94 1.09 1.11 1.02 0.92   Compactin+KLA 0.98 0.90 0.87 0.74 0.77 0.77 0.90 Hadha KLA  Compactin  Compactin+KLA 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA 0.80 1.06 0.91 0.96 0.90 0.90 0.87   Compactin 0.96 1.08 1.02 0.91 0.96 0.95 0.85   Compactin+KLA 0.79 0.96 0.91 0.96 0.91 1.00 0.84 Hadha KLA  Compactin  Compactin+KLA hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA 0.94 0.91 1.08 1.18 0.92 0.71 0.63   Compactin 1.04 1.03 0.88 1.12 1.07 1.06 1.08   Compactin+KLA 0.99 1.00 1.19 1.10 0.84 0.79 0.65 Pla2g1b KLA  Compactin  Compactin+KLA phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA 1.01 1.02 1.03 0.98 1.02 0.93 1.03   Compactin 1.02 0.97 0.98 0.92 1.04 1.06 0.99   Compactin+KLA 1.05 1.01 0.98 1.00 1.01 1.04 1.12 Pla2g4a KLA  Compactin  Compactin+KLA phospholipase A2, group IVA (cytosolic, calcium-dependent) (Pla2g4a), mRNA [NM_008869] KLA 1.14 1.37 1.24 2.94 3.55 3.04 2.98   Compactin 1.01 0.94 1.02 0.96 1.00 0.95 0.92   Compactin+KLA 1.21 1.47 1.38 2.56 3.69 2.90 2.91 Pla2g4b KLA  Compactin  Compactin+KLA phospholipase A2, group IVB (cytosolic) (Pla2g4b), mRNA [NM_145378] KLA 1.01 0.95 0.96 1.07 1.00 1.12 1.12   Compactin 1.00 1.02 0.99 1.04 1.04 0.95 0.95   Compactin+KLA 0.99 0.99 0.92 1.10 1.05 1.17 1.09 Pla2g5 KLA  Compactin  Compactin+KLA phospholipase A2, group V (Pla2g5), transcript variant 2, mRNA [NM_011110] KLA 0.98 0.95 0.94 1.03 0.99 1.15 1.50   Compactin 0.98 1.01 1.02 0.98 0.97 0.97 1.02   Compactin+KLA 0.95 1.02 1.02 0.94 1.04 1.23 1.34 Pla2g6 KLA  Compactin  Compactin+KLA phospholipase A2, group VI (Pla2g6), mRNA [NM_016915] KLA 0.86 1.15 0.83 0.59 0.80 0.78 1.00   Compactin 0.98 1.19 1.05 1.20 1.05 1.12 1.13   Compactin+KLA 0.94 1.10 0.81 0.69 0.72 0.83 1.04 Scd1 KLA  Compactin  Compactin+KLA stearoyl-Coenzyme A desaturase 1 (Scd1), mRNA [NM_009127] KLA 1.12 1.00 0.94 0.97 1.00 1.00 1.07   Compactin 0.98 0.92 0.97 0.94 1.04 1.07 0.70   Compactin+KLA 1.00 0.97 0.99 0.94 1.01 0.95 0.73 Scd2 KLA  Compactin  Compactin+KLA stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA [NM_009128] KLA 0.99 0.85 0.57 0.16 0.23 0.40 1.35   Compactin 1.01 0.92 0.98 0.81 1.03 1.11 0.77   Compactin+KLA 0.88 0.80 0.58 0.18 0.27 0.43 1.22 Scd3 KLA  Compactin  Compactin+KLA stearoyl-coenzyme A desaturase 3 (Scd3), mRNA [NM_024450] KLA 0.95 0.98 1.01 1.10 1.35 1.16 1.27   Compactin 0.99 0.94 1.02 0.99 1.00 1.02 0.93   Compactin+KLA 1.00 0.98 1.02 1.13 1.20 1.11 1.28 Tecr KLA  Compactin  Compactin+KLA trans-2,3-enoyl-CoA reductase KLA 1.11 1.13 1.02 0.92 0.75 0.80 1.08   Compactin 1.07 1.23 1.07 1.10 1.03 1.17 1.19   Compactin+KLA 1.09 1.05 1.00 0.95 0.77 0.83 1.21