Microarray analysis of thioglycolate-elicited macrophage cells treated with Kdo₂-lipid A (KLA) and compactin

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Heatmap of compactin/KLA time course data for lipid category EM (Ratio to control values)

Gene Time course graph Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr Alox5 KLA  Compactin  Compactin+KLA arachidonate 5-lipoxygenase (Alox5), mRNA [NM_009662] KLA 1.00 1.03 1.12 0.88 0.54 0.49 0.72   Compactin 0.99 1.02 1.07 1.06 0.93 0.98 1.01   Compactin+KLA 0.98 1.08 1.08 0.91 0.50 0.49 0.81 Pla2g1b KLA  Compactin  Compactin+KLA phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA 1.01 1.02 1.03 0.98 1.02 0.93 1.03   Compactin 1.02 0.97 0.98 0.92 1.04 1.06 0.99   Compactin+KLA 1.05 1.01 0.98 1.00 1.01 1.04 1.12 Pla2g4a KLA  Compactin  Compactin+KLA phospholipase A2, group IVA (cytosolic, calcium-dependent) (Pla2g4a), mRNA [NM_008869] KLA 1.14 1.37 1.24 2.94 3.55 3.04 2.98   Compactin 1.01 0.94 1.02 0.96 1.00 0.95 0.92   Compactin+KLA 1.21 1.47 1.38 2.56 3.69 2.90 2.91 Pla2g4b KLA  Compactin  Compactin+KLA phospholipase A2, group IVB (cytosolic) (Pla2g4b), mRNA [NM_145378] KLA 1.01 0.95 0.96 1.07 1.00 1.12 1.12   Compactin 1.00 1.02 0.99 1.04 1.04 0.95 0.95   Compactin+KLA 0.99 0.99 0.92 1.10 1.05 1.17 1.09 Pla2g5 KLA  Compactin  Compactin+KLA phospholipase A2, group V (Pla2g5), transcript variant 2, mRNA [NM_011110] KLA 0.98 0.95 0.94 1.03 0.99 1.15 1.50   Compactin 0.98 1.01 1.02 0.98 0.97 0.97 1.02   Compactin+KLA 0.95 1.02 1.02 0.94 1.04 1.23 1.34 Pla2g6 KLA  Compactin  Compactin+KLA phospholipase A2, group VI (Pla2g6), mRNA [NM_016915] KLA 0.86 1.15 0.83 0.59 0.80 0.78 1.00   Compactin 0.98 1.19 1.05 1.20 1.05 1.12 1.13   Compactin+KLA 0.94 1.10 0.81 0.69 0.72 0.83 1.04 Ptgds KLA  Compactin  Compactin+KLA prostaglandin D2 synthase (brain) (Ptgds), mRNA [NM_008963] KLA 0.97 0.99 1.03 1.05 1.04 1.02 1.05   Compactin 1.07 1.02 1.04 1.03 1.05 1.02 1.03   Compactin+KLA 1.05 1.03 1.13 1.12 1.10 0.99 1.07 Ptges KLA  Compactin  Compactin+KLA prostaglandin E synthase (Ptges), mRNA [NM_022415] KLA 1.02 2.22 4.45 10.45 19.28 19.39 18.36   Compactin 0.98 1.14 0.98 1.13 1.05 1.23 1.01   Compactin+KLA 0.90 2.11 4.78 11.00 17.86 18.56 16.72 Ptgs1 KLA  Compactin  Compactin+KLA prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA [NM_008969] KLA 1.02 0.96 0.95 0.56 0.34 0.27 0.28   Compactin 1.03 0.95 1.12 1.05 0.99 1.04 0.86   Compactin+KLA 1.01 0.93 0.88 0.59 0.36 0.35 0.30 Ptgs2 KLA  Compactin  Compactin+KLA prostaglandin-endoperoxide synthase 2 (Ptgs2), mRNA [NM_011198] KLA 1.64 10.05 13.19 27.94 17.76 7.95 5.98   Compactin 1.07 1.01 1.08 1.13 1.13 1.16 1.20   Compactin+KLA 1.44 10.54 15.24 27.67 14.52 5.60 3.78