Structure Database (LMSD)
Common Name
6-amino-hexanoic acid
Systematic Name
6-amino-hexanoic acid
Synonyms
- 6-Aminohexanoic acid
3D model of 6-amino-hexanoic acid
Please note: Where there are chiral atoms but the stereochemistry is undefined, the 3D model takes an arbitrary conformation
Classification
Category
Main Class
Sub Class
Biological Context
6-Aminocaproic acid is an inhibitor of the plasmin activating enzymes streptokinase, fibrinokinase, and urokinase (IC50s = ~8 μM for all in an enzyme assay).1 It is selective for plasmin activating enzymes over trypsin (IC50 = >500 μM). 6-Aminocaproic acid inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner. Ex vivo, 6-aminocaproic acid reduces fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg.2 Formulations containing 6-aminocaproic acid have been used to decrease postoperative blood transfusion rates following knee surgery.3
This information has been provided by Cayman Chemical
References
String Representations
InChiKey (Click to copy)
SLXKOJJOQWFEFD-UHFFFAOYSA-N
InChi (Click to copy)
InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
SMILES (Click to copy)
C(CCCN)CC(=O)O
Other Databases
Calculated Physicochemical Properties
Heavy Atoms
9
Rings
0
Aromatic Rings
0
Rotatable Bonds
5
Van der Waals Molecular Volume
138.30
Topological Polar Surface Area
63.32
Hydrogen Bond Donors
2
Hydrogen Bond Acceptors
2
logP
0.87
Molar Refractivity
35.65
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Created at
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Updated at
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