Microarray analysis of RAW 264.7 cells treated with Kdo₂-lipid A (KLA) and compactin (full time course)

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Heatmap of compactin/KLA time course data for lipid category GL,GP (Ratio to control values)

Gene Time course graph Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr Agpat6 KLA  Compactin  Compactin+KLA 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (Agpat6), mRNA [NM_018743] KLA 0.90 0.91 0.88 0.85 0.83 0.97 1.01   Compactin 0.97 0.89 0.88 0.89 0.89 0.91 0.85   Compactin+KLA 0.89 0.96 0.92 0.74 0.95 0.96 0.93 Cdipt KLA  Compactin  Compactin+KLA CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) (Cdipt), mRNA [NM_026638] KLA 0.79 0.78 0.91 0.99 1.11 1.36 1.73   Compactin 0.85 0.83 0.82 0.94 0.92 1.07 1.37   Compactin+KLA 0.91 0.87 0.90 0.97 1.31 1.51 1.71 Cds1 KLA  Compactin  Compactin+KLA CDP-diacylglycerol synthase 1 (Cds1), mRNA [NM_173370] KLA 0.91 0.95 0.95 1.20 1.17 1.04 1.22   Compactin 0.95 0.99 0.96 0.95 0.91 0.94 0.92   Compactin+KLA 0.98 0.93 1.02 1.13 1.36 1.12 1.17 Chkb KLA  Compactin  Compactin+KLA choline kinase beta (Chkb), mRNA [NM_007692] KLA 1.14 1.02 0.89 0.94 1.23 1.22 1.14   Compactin 1.10 1.14 1.12 1.10 1.17 1.13 1.00   Compactin+KLA 1.05 1.08 1.00 1.00 1.02 1.18 1.21 Chpt1 KLA  Compactin  Compactin+KLA choline phosphotransferase 1 (Chpt1), mRNA [NM_144807] KLA 0.95 1.01 1.00 0.96 0.91 0.97 1.00   Compactin 1.01 1.04 1.04 1.04 0.90 0.89 0.89   Compactin+KLA 0.95 0.96 0.95 1.05 0.91 0.88 0.97 Dgkz KLA  Compactin  Compactin+KLA diacylglycerol kinase zeta (Dgkz), mRNA [NM_138306] KLA 1.13 1.00 0.93 0.63 0.87 1.04 1.03   Compactin 1.18 1.16 1.18 1.36 1.00 1.17 1.07   Compactin+KLA 1.29 1.05 0.92 0.60 0.82 0.89 1.03 Etnk1 KLA  Compactin  Compactin+KLA gb|PREDICTED: Mus musculus ethanolamine kinase 1 (Etnk1), mRNA [XM_908334] KLA 0.97 1.06 1.19 2.08 1.89 1.71 1.57   Compactin 0.95 1.03 0.98 1.02 0.88 0.90 0.97   Compactin+KLA 1.10 1.03 1.11 2.05 1.96 1.85 1.70 Gpam KLA  Compactin  Compactin+KLA glycerol-3-phosphate acyltransferase, mitochondrial (Gpam), nuclear gene encoding mitochondrial protein, mRNA [NM_008149] KLA 1.14 1.04 0.96 1.10 1.13 1.24 1.68   Compactin 1.04 1.08 0.99 1.00 1.01 1.20 1.03   Compactin+KLA 0.95 1.10 1.07 1.05 0.95 1.30 1.60 Pcyt1a KLA  Compactin  Compactin+KLA 10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:B930020C23 product:phosphate cytidylyltransferase 1, choline, alpha isoform, full insert sequence [AK163685] KLA 0.95 0.92 1.02 1.02 1.58 1.16 0.87   Compactin 0.93 0.97 0.97 0.96 0.81 0.84 0.92   Compactin+KLA 1.00 0.89 0.89 0.90 1.34 1.35 0.94 Pcyt1a KLA  Compactin  Compactin+KLA phosphate cytidylyltransferase 1, choline, alpha isoform (Pcyt1a), mRNA [NM_009981] KLA 0.99 0.92 1.17 0.90 1.50 1.44 1.44   Compactin 1.00 1.07 1.00 0.97 0.83 0.79 0.87   Compactin+KLA 1.05 0.89 1.16 0.93 1.36 1.44 1.47 Pcyt2 KLA  Compactin  Compactin+KLA phosphate cytidylyltransferase 2, ethanolamine (Pcyt2), mRNA [NM_024229] KLA 1.04 1.09 0.98 0.71 0.62 0.79 0.66   Compactin 1.08 1.07 1.16 1.25 1.27 1.09 0.94   Compactin+KLA 1.17 1.10 1.07 0.67 0.66 0.76 0.64 Pemt KLA  Compactin  Compactin+KLA phosphatidylethanolamine N-methyltransferase (Pemt), nuclear gene encoding mitochondrial protein, mRNA [NM_008819] KLA 0.97 1.08 1.02 1.06 1.00 0.91 0.95   Compactin 1.04 1.05 1.04 1.01 0.96 1.10 1.01   Compactin+KLA 0.89 1.00 1.03 1.14 0.91 0.90 0.99 Pisd KLA  Compactin  Compactin+KLA phosphatidylserine decarboxylase (Pisd), mRNA [NM_177298] KLA 0.90 0.89 0.90 0.89 1.10 1.35 1.14   Compactin 0.98 1.00 1.01 0.91 1.06 1.03 1.10   Compactin+KLA 0.94 0.85 0.96 0.89 1.16 1.18 1.05 Pla2g1b KLA  Compactin  Compactin+KLA phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA 1.05 1.00 0.97 0.93 1.00 1.00 1.08   Compactin 1.20 1.03 1.05 0.98 1.01 1.00 0.96   Compactin+KLA 0.93 1.01 0.95 1.04 1.02 0.94 1.00 Pld1 KLA  Compactin  Compactin+KLA phospholipase D1 (Pld1), mRNA [NM_008875] KLA 0.96 1.02 0.91 0.91 1.19 1.44 1.46   Compactin 1.01 0.99 0.94 1.02 0.97 0.98 1.45   Compactin+KLA 1.02 1.03 0.90 0.94 1.31 1.99 1.64 Pnpla3 KLA  Compactin  Compactin+KLA patatin-like phospholipase domain containing 3 (Pnpla3), mRNA [NM_054088] KLA 0.97 0.97 1.02 1.00 0.98 0.99 0.95   Compactin 1.04 0.97 1.02 1.01 1.06 0.98 1.00   Compactin+KLA 1.00 0.99 1.02 0.96 1.01 1.02 1.00 Ppap2a KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase 2a (Ppap2a), transcript variant 2, mRNA [NM_008903] KLA 1.02 1.10 1.18 1.32 1.46 1.43 1.53   Compactin 1.20 1.18 1.08 1.18 1.03 0.99 1.32   Compactin+KLA 1.18 1.16 1.17 1.19 1.31 1.49 1.57 Ppap2b KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2B (Ppap2b), mRNA [NM_080555] KLA 0.97 1.03 1.01 0.97 0.93 0.90 1.03   Compactin 0.90 0.87 0.96 1.02 1.10 1.01 0.93   Compactin+KLA 0.97 0.91 0.97 0.95 0.97 0.92 1.02 Ppap2c KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2c KLA 1.09 1.07 1.14 1.11 0.96 1.04 0.87   Compactin 1.12 1.17 1.19 1.23 0.89 1.11 1.33   Compactin+KLA 1.15 1.03 1.10 1.16 1.07 1.06 0.89 Ppap2c KLA  Compactin  Compactin+KLA phosphatidic acid phosphatase type 2c (Ppap2c), mRNA [NM_015817] KLA 0.97 1.02 1.10 1.05 0.99 0.94 0.88   Compactin 1.03 1.02 0.95 0.92 0.97 1.13 1.13   Compactin+KLA 0.97 1.04 1.07 0.93 1.01 1.10 0.96 Ptdss1 KLA  Compactin  Compactin+KLA phosphatidylserine synthase 1 (Ptdss1), mRNA [NM_008959] KLA 1.02 1.00 1.12 1.12 1.07 1.07 1.12   Compactin 1.15 1.14 1.04 1.21 1.10 1.01 1.05   Compactin+KLA 1.16 1.02 1.06 1.05 1.03 1.10 1.16 Ptdss2 KLA  Compactin  Compactin+KLA phosphatidylserine synthase 2 (Ptdss2), mRNA [NM_013782] KLA 1.00 0.92 0.94 0.77 0.80 0.92 1.13   Compactin 1.07 1.02 1.04 1.10 1.04 0.96 0.78   Compactin+KLA 1.09 0.98 1.00 0.80 0.83 0.89 1.11