Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Biosynthesis of unsaturated fatty acids (mmu01040)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
Acaa1a
KLA  Compactin  Compactin+KLA
 NM_130864 acetyl-Coenzyme A acyltransferase 1A (Acaa1a), mRNA [NM_130864] KLA0.940 0.820 0.920 0.910 0.770 0.760 0.430
Compactin1.060 0.930 0.970 0.940 1.030 1.140 0.770
KLA/Compactin0.940 0.950 0.810 0.720 0.820 0.670 0.430
Acaa1a
KLA  Compactin  Compactin+KLA
 NM_130864 acetyl-Coenzyme A acyltransferase 1A (Acaa1a), mRNA [NM_130864] KLA1.080 0.910 0.980 0.920 0.690 0.730 0.430
Compactin1.050 1.020 1.010 1.150 0.930 1.130 0.760
KLA/Compactin1.030 0.930 0.900 0.890 0.780 0.860 0.400
Acaa1a
KLA  Compactin  Compactin+KLA
 NM_130864 acetyl-Coenzyme A acyltransferase 1A (Acaa1a), mRNA [NM_130864] KLA1.380 1.180 1.110 0.980 1.070 0.910 0.470
Compactin1.310 1.220 1.140 1.360 1.280 1.360 0.980
KLA/Compactin1.270 1.180 1.070 1.040 1.110 0.750 0.470
Acaa1b
KLA  Compactin  Compactin+KLA
 NM_146230 acetyl-Coenzyme A acyltransferase 1B (Acaa1b), mRNA [NM_146230] KLA1.220 1.210 1.050 1.140 0.910 0.840 0.570
Compactin1.260 1.090 1.250 1.250 1.160 1.140 0.800
KLA/Compactin1.280 0.760 1.190 1.140 0.930 0.770 0.550
Acot1
KLA  Compactin  Compactin+KLA
 118129966 acyl-CoA thioesterase 1 KLA0.860 0.910 0.780 0.500 0.390 0.390 0.390
Compactin0.880 0.990 1.010 1.010 0.930 0.860 0.930
KLA/Compactin0.900 0.860 0.850 0.510 0.380 0.380 0.320
Acot1
KLA  Compactin  Compactin+KLA
 NM_012006 acyl-CoA thioesterase 1 (Acot1), mRNA [NM_012006] KLA0.990 0.930 0.820 0.490 0.380 0.390 0.360
Compactin0.940 0.930 1.000 1.050 0.930 0.830 0.870
KLA/Compactin0.970 0.820 0.860 0.530 0.390 0.380 0.340
Acot2
KLA  Compactin  Compactin+KLA
 NM_134188 acyl-CoA thioesterase 2 (Acot2), nuclear gene encoding mitochondrial protein, mRNA [NM_134188] KLA0.970 0.980 0.930 0.790 0.880 0.940 0.750
Compactin1.030 1.060 1.070 1.100 1.090 0.830 1.700
KLA/Compactin1.010 0.980 0.920 0.820 0.830 0.950 0.570
Acot3
KLA  Compactin  Compactin+KLA
 NM_134246 acyl-CoA thioesterase 3 (Acot3), mRNA [NM_134246] KLA1.100 1.000 0.980 1.070 0.960 1.070 0.870
Compactin1.020 1.030 1.060 1.000 0.980 1.000 0.950
KLA/Compactin1.020 1.000 0.990 1.010 1.030 1.060 0.980
Acot4
KLA  Compactin  Compactin+KLA
 NM_134247 acyl-CoA thioesterase 4 (Acot4), mRNA [NM_134247] KLA0.960 0.990 0.940 0.960 1.020 0.940 0.980
Compactin0.960 1.000 1.000 0.990 0.930 1.020 1.150
KLA/Compactin1.060 1.050 1.010 1.020 0.930 0.940 0.960
Acot4
KLA  Compactin  Compactin+KLA
 NM_134247 acyl-CoA thioesterase 4 (Acot4), mRNA [NM_134247] KLA1.010 0.930 0.920 0.980 0.900 0.820 0.930
Compactin1.040 0.930 1.060 1.020 1.220 1.170 1.110
KLA/Compactin0.960 0.990 1.030 0.940 1.040 0.910 0.840
Acot5
KLA  Compactin  Compactin+KLA
 NM_145444 acyl-CoA thioesterase 5 (Acot5), mRNA [NM_145444] KLA1.050 1.080 1.090 1.100 1.050 1.010 1.040
Compactin1.070 1.030 1.040 1.000 1.010 1.000 1.010
KLA/Compactin1.040 0.920 1.100 1.000 1.000 1.020 1.000
Acot7
KLA  Compactin  Compactin+KLA
 NM_133348 acyl-CoA thioesterase 7 (Acot7), mRNA [NM_133348] KLA1.040 1.080 1.230 1.400 1.420 1.820 1.890
Compactin0.970 1.010 0.970 1.030 1.190 1.350 1.560
KLA/Compactin1.020 1.050 1.060 1.330 1.630 2.330 2.610
Acox1
KLA  Compactin  Compactin+KLA
 NM_015729 acyl-Coenzyme A oxidase 1, palmitoyl (Acox1), mRNA [NM_015729] KLA0.850 1.000 0.960 0.910 1.320 1.320 1.570
Compactin0.980 1.050 0.990 0.970 0.980 1.060 1.020
KLA/Compactin1.020 0.930 0.970 1.050 1.180 1.510 2.020
Acox1
KLA  Compactin  Compactin+KLA
 NM_015729 acyl-Coenzyme A oxidase 1, palmitoyl (Acox1), mRNA [NM_015729] KLA0.950 0.890 0.850 0.660 1.220 1.090 0.790
Compactin0.960 1.060 1.070 1.120 1.060 0.960 0.930
KLA/Compactin0.980 0.870 0.820 0.660 1.170 1.180 0.800
Acox3
KLA  Compactin  Compactin+KLA
 34328333 acyl-Coenzyme A oxidase 3, pristanoyl KLA0.740 0.840 0.600 0.640 0.650 0.570 0.660
Compactin0.820 0.910 0.910 0.910 0.940 0.950 0.780
KLA/Compactin1.040 0.860 0.630 0.620 0.510 0.510 0.790
Acox3
KLA  Compactin  Compactin+KLA
 NM_030721 acyl-Coenzyme A oxidase 3, pristanoyl (Acox3), mRNA [NM_030721] KLA0.880 0.820 0.710 0.690 0.570 0.620 0.840
Compactin0.840 0.870 0.990 1.040 1.060 1.010 0.870
KLA/Compactin0.960 0.780 0.670 0.670 0.580 0.630 0.780
Baat
KLA  Compactin  Compactin+KLA
 NM_007519 bile acid-Coenzyme A: amino acid N-acyltransferase (Baat), mRNA [NM_007519] KLA0.970 1.050 1.110 1.020 1.000 1.100 1.030
Compactin0.960 0.990 1.000 0.980 0.940 1.030 1.000
KLA/Compactin0.950 1.000 1.010 1.000 1.050 1.010 0.940
Baat
KLA  Compactin  Compactin+KLA
 NM_007519 bile acid-Coenzyme A: amino acid N-acyltransferase (Baat), mRNA [NM_007519] KLA1.000 1.140 1.010 1.030 0.980 1.020 0.940
Compactin0.870 1.030 1.000 1.010 1.020 0.940 1.010
KLA/Compactin0.950 1.160 1.030 1.050 1.010 0.960 0.940
Elovl2
KLA  Compactin  Compactin+KLA
 NM_019423 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), mRNA [NM_019423] KLA1.030 1.070 0.970 0.970 0.950 0.990 0.970
Compactin0.990 1.060 1.020 0.950 1.090 1.050 0.970
KLA/Compactin1.010 1.020 0.990 1.080 1.030 1.010 1.000
Elovl5
KLA  Compactin  Compactin+KLA
 NM_134255 ELOVL family member 5, elongation of long chain fatty acids (yeast) (Elovl5), mRNA [NM_134255] KLA1.040 0.990 0.900 0.580 0.490 0.610 0.630
Compactin1.020 1.030 1.210 1.080 1.030 1.170 1.220
KLA/Compactin1.100 0.920 0.970 0.540 0.520 0.710 0.640
Elovl5
KLA  Compactin  Compactin+KLA
 NM_134255 ELOVL family member 5, elongation of long chain fatty acids (yeast) (Elovl5), mRNA [NM_134255] KLA1.100 1.030 1.120 0.740 0.620 0.770 0.840
Compactin1.170 1.050 1.100 1.200 1.040 1.210 1.330
KLA/Compactin1.180 1.050 1.050 0.680 0.600 0.750 0.710
Elovl6
KLA  Compactin  Compactin+KLA
 91598889 ELOVL family member 6, elongation of long chain fatty acids (yeast) KLA0.960 1.050 0.620 0.450 0.360 0.330 0.420
Compactin0.910 1.010 0.870 0.910 1.080 1.020 0.840
KLA/Compactin0.890 0.980 0.630 0.430 0.270 0.310 0.550
Elovl6
KLA  Compactin  Compactin+KLA
 NM_130450 ELOVL family member 6, elongation of long chain fatty acids (yeast) (Elovl6), mRNA [NM_130450] KLA1.080 0.990 0.820 0.460 0.340 0.390 0.480
Compactin1.170 1.180 1.180 1.210 1.010 1.030 1.000
KLA/Compactin1.140 1.010 0.860 0.490 0.320 0.280 0.410
Fads1
KLA  Compactin  Compactin+KLA
 NM_146094 fatty acid desaturase 1 (Fads1), mRNA [NM_146094] KLA1.060 0.960 0.910 0.750 0.540 0.570 0.770
Compactin1.180 1.050 1.050 1.230 0.810 0.850 0.870
KLA/Compactin1.170 0.870 1.170 0.770 0.490 0.490 0.830
Fads2
KLA  Compactin  Compactin+KLA
 NM_019699 fatty acid desaturase 2 (Fads2), mRNA [NM_019699] KLA1.050 0.980 1.100 0.900 0.700 0.540 0.730
Compactin1.060 1.150 1.120 1.070 0.850 0.980 0.740
KLA/Compactin1.140 1.010 1.210 1.030 0.680 0.540 0.960
Hadha
KLA  Compactin  Compactin+KLA
 AK050856 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA0.890 1.000 1.070 0.990 1.030 1.070 0.900
Compactin1.060 1.020 0.980 0.990 1.070 0.990 0.980
KLA/Compactin0.960 1.060 0.990 1.060 1.000 0.970 0.920
Hadha
KLA  Compactin  Compactin+KLA
 NM_178878 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA1.060 0.930 0.900 1.160 1.030 1.080 1.510
Compactin1.080 0.950 0.940 0.940 1.050 1.070 0.920
KLA/Compactin0.950 1.020 0.940 0.980 1.080 1.210 1.590
Hsd17b12
KLA  Compactin  Compactin+KLA
 AK076088 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810004A21 product:hydroxysteroid (17-beta) dehydrogenase 12, full insert sequence. [AK076088] KLA1.520 1.870 1.120 0.910 1.130 1.200 0.860
Compactin1.000 0.950 0.920 0.900 1.160 1.060 1.140
KLA/Compactin1.400 1.680 1.110 0.970 1.050 0.950 0.980
Hsd17b12
KLA  Compactin  Compactin+KLA
 NM_019657 hydroxysteroid (17-beta) dehydrogenase 12 (Hsd17b12), mRNA [NM_019657] KLA0.840 1.050 0.810 1.100 1.530 1.020 0.730
Compactin1.070 0.940 0.880 0.770 1.090 1.080 1.070
KLA/Compactin1.040 1.020 0.950 0.950 1.050 0.840 1.110
Hsd17b12
KLA  Compactin  Compactin+KLA
 NM_019657 hydroxysteroid (17-beta) dehydrogenase 12 (Hsd17b12), mRNA [NM_019657] KLA1.100 1.110 1.350 1.180 1.290 1.370 0.980
Compactin1.150 1.090 1.210 1.060 1.110 1.180 1.190
KLA/Compactin1.240 1.090 1.380 1.150 1.320 1.060 0.930
Pecr
KLA  Compactin  Compactin+KLA
 NM_023523 peroxisomal trans-2-enoyl-CoA reductase (Pecr), mRNA [NM_023523] KLA0.970 1.080 1.090 1.030 0.730 0.660 0.630
Compactin1.010 1.060 1.170 1.060 1.130 0.970 0.910
KLA/Compactin0.880 1.090 1.020 1.090 0.820 0.610 0.500
Ptplb
KLA  Compactin  Compactin+KLA
 AF169286 protein tyrosine phosphatase-like protein PTPLB (Ptplb) mRNA, complete cds. [AF169286] KLA1.180 1.170 1.140 1.290 1.060 1.020 1.050
Compactin1.150 1.060 1.080 1.040 1.070 1.030 0.980
KLA/Compactin1.020 1.070 1.320 1.400 1.080 1.050 1.300
Ptplb
KLA  Compactin  Compactin+KLA
 NM_023587 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b (Ptplb), mRNA [NM_023587] KLA1.060 1.080 1.060 0.990 0.960 1.010 0.860
Compactin1.120 1.050 0.960 0.970 0.980 0.980 1.050
KLA/Compactin1.000 1.080 1.090 1.050 0.930 0.870 0.900
Scd1
KLA  Compactin  Compactin+KLA
 NM_009127 stearoyl-Coenzyme A desaturase 1 (Scd1), mRNA [NM_009127] KLA1.090 1.060 1.010 0.690 0.490 0.490 0.770
Compactin1.070 1.210 1.080 1.330 1.070 1.060 0.790
KLA/Compactin1.220 1.020 0.890 0.720 0.530 0.510 0.710
Scd2
KLA  Compactin  Compactin+KLA
 NM_009128 stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA [NM_009128] KLA0.930 0.800 0.500 0.210 0.320 0.350 0.410
Compactin1.010 0.880 0.930 0.900 0.790 0.820 0.640
KLA/Compactin0.920 0.740 0.620 0.210 0.220 0.260 0.350
Scd3
KLA  Compactin  Compactin+KLA
 NM_024450 stearoyl-coenzyme A desaturase 3 (Scd3), mRNA [NM_024450] KLA1.130 0.930 1.050 1.100 1.080 1.120 1.150
Compactin1.010 0.960 1.010 0.990 1.080 1.080 1.010
KLA/Compactin0.970 1.070 1.040 1.050 1.130 1.220 1.170
Scd4
KLA  Compactin  Compactin+KLA
 BC038322 stearoyl-coenzyme A desaturase 4, mRNA (cDNA clone IMAGE:1479917), complete cds. [BC038322] KLA0.930 1.050 1.030 1.010 1.000 1.010 1.060
Compactin1.060 1.010 1.020 0.950 1.050 0.970 1.020
KLA/Compactin1.040 1.100 1.070 1.020 1.100 0.990 1.040
Scd4
KLA  Compactin  Compactin+KLA
 NM_183216 stearoyl-coenzyme A desaturase 4 (Scd4), mRNA [NM_183216] KLA1.000 1.020 0.930 1.010 1.000 0.940 0.950
Compactin1.090 1.070 1.070 1.040 1.070 1.040 1.000
KLA/Compactin1.030 0.990 0.990 1.000 0.910 0.980 1.010
Tecr
KLA  Compactin  Compactin+KLA
 NM_134118 trans-2,3-enoyl-CoA reductase KLA1.340 1.260 1.270 1.020 0.960 0.920 1.100
Compactin1.260 1.190 1.180 1.440 1.140 1.090 1.080
KLA/Compactin1.260 1.130 1.180 1.050 1.070 0.840 0.950