Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: One carbon pool by folate (mmu00670)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
1110019K
23Rik
KLA  Compactin  Compactin+KLA
 124301197 RIKEN cDNA 1110019K23 gene KLA1.040 1.040 1.190 1.350 1.040 1.050 1.480
Compactin1.060 1.110 1.050 1.080 1.030 1.070 1.430
KLA/Compactin1.100 1.010 1.130 1.280 1.230 1.140 1.570
Aldh1l1
KLA  Compactin  Compactin+KLA
 NM_027406 aldehyde dehydrogenase 1 family, member L1 (Aldh1l1), mRNA [NM_027406] KLA0.990 1.010 1.050 1.010 1.020 1.040 1.160
Compactin1.090 1.100 0.950 1.020 1.050 1.030 0.840
KLA/Compactin1.120 0.940 1.030 1.100 1.210 1.170 1.260
Aldh1l2
KLA  Compactin  Compactin+KLA
 NM_153543 aldehyde dehydrogenase 1 family, member L2 (Aldh1l2), mRNA [NM_153543] KLA0.810 0.830 0.870 0.770 1.150 1.550 1.630
Compactin0.810 0.880 0.950 1.110 1.160 1.000 1.450
KLA/Compactin0.830 0.840 0.810 0.960 1.340 1.720 1.470
Aldh1l2
KLA  Compactin  Compactin+KLA
 NM_153543 aldehyde dehydrogenase 1 family, member L2 (Aldh1l2), mRNA [NM_153543] KLA0.850 0.990 0.960 0.950 1.390 2.370 4.440
Compactin0.860 0.900 0.980 0.990 1.000 0.950 1.380
KLA/Compactin0.900 0.970 0.950 1.120 1.520 2.690 4.540
Atic
KLA  Compactin  Compactin+KLA
 NM_026195 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (Atic), mRNA [NM_026195] KLA0.930 0.820 0.780 0.810 0.580 0.620 0.640
Compactin1.040 0.910 1.050 0.870 1.020 0.940 0.800
KLA/Compactin0.900 1.030 0.980 0.710 0.730 0.560 0.570
Dhfr
KLA  Compactin  Compactin+KLA
 L26316 dihydrofolate reductase (dhfr) mRNA, complete cds. [L26316] KLA1.100 1.100 0.980 0.830 0.560 0.630 0.740
Compactin1.060 1.060 1.060 1.180 0.920 1.000 0.820
KLA/Compactin1.060 1.040 1.020 0.750 0.490 0.390 0.580
Dhfr
KLA  Compactin  Compactin+KLA
 NM_010049 dihydrofolate reductase (Dhfr), mRNA [NM_010049] KLA0.940 0.990 0.860 0.700 0.460 0.450 0.650
Compactin0.960 0.970 0.900 0.960 0.890 0.810 0.740
KLA/Compactin0.840 0.930 0.760 0.610 0.370 0.350 0.530
Dhfr
KLA  Compactin  Compactin+KLA
 NM_010049 dihydrofolate reductase (Dhfr), mRNA [NM_010049] KLA1.410 1.200 0.930 0.610 0.590 0.570 0.650
Compactin1.350 1.280 1.140 1.300 0.890 0.820 0.770
KLA/Compactin1.310 1.080 0.870 0.560 0.490 0.440 0.570
Ftcd
KLA  Compactin  Compactin+KLA
 NM_080845 formiminotransferase cyclodeaminase (Ftcd), mRNA [NM_080845] KLA1.070 1.020 0.990 1.030 0.930 0.960 0.940
Compactin1.050 0.950 1.020 0.960 1.050 1.040 0.990
KLA/Compactin0.980 1.030 1.030 0.990 0.910 1.060 0.940
Gart
KLA  Compactin  Compactin+KLA
 AK168445 13 days embryo liver cDNA, RIKEN full-length enriched library, clone:I920021A03 product:phosphoribosylglycinamide formyltransferase, full insert sequence. [AK168445] KLA0.820 0.810 0.870 0.690 0.450 0.430 0.490
Compactin0.870 0.900 0.810 0.960 0.820 0.930 0.750
KLA/Compactin0.870 0.920 0.840 0.690 0.440 0.370 0.360
Gart
KLA  Compactin  Compactin+KLA
 NM_010256 phosphoribosylglycinamide formyltransferase (Gart), mRNA [NM_010256] KLA1.100 1.010 1.180 0.680 0.740 0.650 0.420
Compactin1.070 1.060 1.090 1.050 1.140 0.960 0.830
KLA/Compactin1.030 1.110 1.160 0.750 0.630 0.540 0.340
LOC10003
9707
KLA  Compactin  Compactin+KLA
 XM_001473273 gb|PREDICTED: Mus musculus similar to 5, 10-methenyltetrahydrofolate synthetase (LOC100039707), mRNA [XM_001473273] KLA1.030 1.130 1.040 1.040 0.990 1.040 0.910
Compactin0.930 1.010 1.020 1.040 0.980 0.990 1.030
KLA/Compactin1.010 0.940 0.980 1.160 1.050 0.960 0.950
Mtfmt
KLA  Compactin  Compactin+KLA
 NM_027134 mitochondrial methionyl-tRNA formyltransferase (Mtfmt), nuclear gene encoding mitochondrial protein, mRNA [NM_027134] KLA1.100 1.020 1.850 1.300 0.910 1.080 0.950
Compactin1.190 1.100 1.160 1.130 0.950 1.040 1.090
KLA/Compactin1.180 1.020 1.590 1.330 0.950 0.830 0.800
Mthfd1
KLA  Compactin  Compactin+KLA
 20270274 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase KLA1.040 1.060 1.060 0.790 0.570 0.540 0.500
Compactin1.160 1.050 1.180 1.170 0.990 0.780 0.800
KLA/Compactin1.140 0.960 1.160 0.840 0.520 0.410 0.420
Mthfd1
KLA  Compactin  Compactin+KLA
 NM_138745 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase (Mthfd1), mRNA [NM_138745] KLA1.060 0.980 1.020 0.780 0.580 0.440 0.500
Compactin1.020 1.110 1.100 1.110 0.880 0.940 0.760
KLA/Compactin1.090 1.030 1.130 0.830 0.500 0.420 0.460
Mthfd1l
KLA  Compactin  Compactin+KLA
 NM_172308 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (Mthfd1l), mRNA [NM_172308] KLA1.390 1.100 1.230 0.970 1.020 1.020 0.640
Compactin1.180 1.210 1.080 1.210 1.100 1.020 1.100
KLA/Compactin1.270 1.150 1.080 1.000 1.050 0.870 0.720
Mthfd2
KLA  Compactin  Compactin+KLA
 NM_008638 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase (Mthfd2), nuclear gene encoding mitochondrial protein, mRNA [NM_008638] KLA0.920 0.890 0.880 1.130 1.720 1.310 0.960
Compactin0.930 1.030 1.040 0.920 1.100 1.060 1.440
KLA/Compactin0.910 0.910 1.030 1.130 1.570 1.530 1.210
Mthfr
KLA  Compactin  Compactin+KLA
 AF404274 methylenetetrahydrofolate reductase short isoform (Mthfr) mRNA, partial cds; alternatively spliced. [AF404274] KLA0.950 1.000 0.990 1.050 1.040 0.950 1.040
Compactin1.010 0.970 0.850 0.990 1.040 0.920 1.000
KLA/Compactin1.010 1.000 1.030 1.000 1.010 1.050 1.000
Mthfr
KLA  Compactin  Compactin+KLA
 NM_010840 5,10-methylenetetrahydrofolate reductase (Mthfr), mRNA [NM_010840] KLA0.950 0.940 1.110 1.530 2.960 2.610 1.500
Compactin0.990 1.040 1.090 1.020 0.990 0.950 0.990
KLA/Compactin0.980 0.920 1.070 1.740 2.100 2.400 1.410
Mthfr
KLA  Compactin  Compactin+KLA
 NM_010840 5,10-methylenetetrahydrofolate reductase (Mthfr), mRNA [NM_010840] KLA1.000 0.950 1.010 1.190 1.400 1.540 1.070
Compactin0.950 0.940 0.980 0.960 0.960 0.970 0.920
KLA/Compactin0.940 0.960 1.010 1.270 1.450 1.570 1.120
Mthfr
KLA  Compactin  Compactin+KLA
 NM_010840 5,10-methylenetetrahydrofolate reductase (Mthfr), mRNA [NM_010840] KLA1.130 0.850 0.860 2.740 5.180 4.620 1.850
Compactin1.090 1.040 1.130 1.330 1.200 0.930 1.100
KLA/Compactin1.210 0.760 0.740 3.840 6.370 4.630 1.400
Mthfs
KLA  Compactin  Compactin+KLA
 NM_026829 5, 10-methenyltetrahydrofolate synthetase (Mthfs), mRNA [NM_026829] KLA0.980 1.150 1.270 2.250 1.350 1.440 1.160
Compactin0.940 0.950 0.950 1.020 1.080 0.890 0.770
KLA/Compactin0.960 1.150 1.280 2.110 1.710 1.790 1.600
Mtr
KLA  Compactin  Compactin+KLA
 AK037599 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130029B16 product:5-methyltetrahydrofolate-homocysteine methyltransferase, full insert sequence. [AK037599] KLA1.040 0.990 1.050 0.860 0.800 0.880 0.800
Compactin1.090 1.040 1.030 1.080 0.930 0.930 0.820
KLA/Compactin1.120 1.020 0.960 0.900 0.780 0.760 0.800
Mtr
KLA  Compactin  Compactin+KLA
 NM_001081128 5-methyltetrahydrofolate-homocysteine methyltransferase (Mtr), mRNA [NM_001081128] KLA0.780 0.960 0.840 0.810 0.870 0.660 0.820
Compactin0.910 0.780 0.820 0.710 0.960 1.110 0.860
KLA/Compactin0.810 1.000 0.930 0.800 0.560 0.570 0.840
Mtr
KLA  Compactin  Compactin+KLA
 NM_001081128 5-methyltetrahydrofolate-homocysteine methyltransferase (Mtr), mRNA [NM_001081128] KLA0.850 0.990 0.840 0.930 0.920 0.660 0.700
Compactin0.930 0.910 0.890 0.770 0.980 1.120 0.760
KLA/Compactin1.010 1.060 0.960 0.790 0.640 0.620 0.820
Shmt1
KLA  Compactin  Compactin+KLA
 NM_009171 serine hydroxymethyltransferase 1 (soluble) (Shmt1), mRNA [NM_009171] KLA0.870 1.060 0.980 0.760 0.850 0.700 0.740
Compactin1.130 0.900 0.960 0.870 0.850 1.120 0.770
KLA/Compactin0.780 1.050 0.850 0.830 0.560 0.610 0.870
Shmt1
KLA  Compactin  Compactin+KLA
 NM_009171 serine hydroxymethyltransferase 1 (soluble) (Shmt1), mRNA [NM_009171] KLA0.990 0.970 1.060 0.850 0.520 0.540 0.430
Compactin1.020 1.030 1.020 1.010 0.940 0.950 0.690
KLA/Compactin0.910 1.120 0.910 0.680 0.480 0.410 0.430
Shmt1
KLA  Compactin  Compactin+KLA
 NM_009171 serine hydroxymethyltransferase 1 (soluble) (Shmt1), mRNA [NM_009171] KLA1.140 1.210 1.160 0.930 0.780 0.800 0.720
Compactin1.150 1.090 1.100 1.120 0.960 0.980 0.840
KLA/Compactin1.110 1.220 1.230 1.010 0.700 0.580 0.810
Shmt2
KLA  Compactin  Compactin+KLA
 NM_028230 serine hydroxymethyltransferase 2 (mitochondrial) (Shmt2), nuclear gene encoding mitochondrial protein, mRNA [NM_028230] KLA1.030 1.060 0.880 0.810 0.840 0.990 0.910
Compactin1.070 1.050 1.140 1.090 1.070 0.950 1.020
KLA/Compactin1.070 1.050 1.090 0.860 0.780 1.010 0.690
Tyms
KLA  Compactin  Compactin+KLA
 NM_021288 thymidylate synthase (Tyms), mRNA [NM_021288] KLA0.850 0.860 0.710 0.760 0.460 0.340 0.400
Compactin0.880 0.880 0.940 0.840 0.900 0.960 0.640
KLA/Compactin0.900 0.940 0.850 0.690 0.420 0.290 0.380
Tyms
KLA  Compactin  Compactin+KLA
 NM_021288 thymidylate synthase (Tyms), mRNA [NM_021288] KLA1.040 0.890 0.950 0.910 0.560 0.440 0.460
Compactin1.090 0.990 1.120 1.030 1.000 0.950 0.620
KLA/Compactin1.110 0.960 0.890 0.990 0.510 0.320 0.360
Tyms
KLA  Compactin  Compactin+KLA
 X14489 gb|M.musculus thymidylate synthase (TS) gene exons 5 - 7. [X14489] KLA1.030 0.920 0.920 0.870 0.980 0.900 0.990
Compactin0.990 1.030 0.980 0.970 1.100 0.990 0.900
KLA/Compactin0.940 0.940 1.010 0.860 0.900 0.990 0.950