Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Glycosphingolipid biosynthesis - globo series (mmu00603)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
A4galt
KLA  Compactin  Compactin+KLA
 195546943 alpha 1,4-galactosyltransferase KLA0.970 0.960 1.010 1.000 1.070 0.930 1.010
Compactin0.930 1.000 0.980 0.980 1.000 0.970 0.970
KLA/Compactin1.020 1.000 1.010 0.970 1.030 1.030 0.990
B3galnt1
KLA  Compactin  Compactin+KLA
 NM_020026 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1 (B3galnt1), mRNA [NM_020026] KLA0.920 0.900 0.870 0.960 0.960 1.240 1.580
Compactin1.040 1.100 0.950 1.050 0.980 1.050 1.090
KLA/Compactin0.940 0.940 1.000 0.890 1.260 1.530 1.720
B3galnt1
KLA  Compactin  Compactin+KLA
 NM_020026 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1 (B3galnt1), mRNA [NM_020026] KLA1.400 1.080 1.030 1.050 0.960 1.410 1.470
Compactin0.930 1.160 1.200 1.110 1.020 0.890 1.170
KLA/Compactin1.070 0.870 1.060 1.040 1.190 1.540 1.890
B3galt5
KLA  Compactin  Compactin+KLA
 NM_033149 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3galt5), transcript variant 1, mRNA [NM_033149] KLA1.000 0.930 1.030 0.990 0.950 1.000 1.180
Compactin1.050 0.980 1.000 0.960 1.020 1.000 1.040
KLA/Compactin1.010 1.010 1.020 1.030 1.020 0.990 0.960
Fut1
KLA  Compactin  Compactin+KLA
 NM_008051 fucosyltransferase 1 (Fut1), mRNA [NM_008051] KLA1.010 0.960 0.960 1.020 0.960 0.960 0.940
Compactin0.980 1.010 0.970 1.020 0.980 1.030 1.000
KLA/Compactin1.020 0.980 1.000 0.970 0.920 0.920 1.000
Fut2
KLA  Compactin  Compactin+KLA
 NM_018876 fucosyltransferase 2 (Fut2), mRNA [NM_018876] KLA1.040 1.000 0.980 1.020 0.940 0.950 0.920
Compactin0.920 0.960 1.000 0.970 0.980 1.030 1.030
KLA/Compactin0.940 0.980 1.010 0.970 0.900 0.900 1.040
Fut2
KLA  Compactin  Compactin+KLA
 NM_018876 fucosyltransferase 2 (Fut2), mRNA [NM_018876] KLA1.060 0.990 0.980 1.040 1.060 1.000 1.000
Compactin0.950 1.030 0.960 0.950 1.030 0.970 0.900
KLA/Compactin1.040 0.960 0.950 0.980 1.020 1.010 1.010
Fut9
KLA  Compactin  Compactin+KLA
 NM_010243 fucosyltransferase 9 (Fut9), mRNA [NM_010243] KLA0.960 1.010 0.990 1.000 1.010 0.980 1.000
Compactin1.100 1.030 1.050 1.000 0.990 0.990 1.020
KLA/Compactin1.040 0.990 0.990 1.030 0.990 0.930 1.030
Fut9
KLA  Compactin  Compactin+KLA
 NM_010243 fucosyltransferase 9 (Fut9), mRNA [NM_010243] KLA1.000 0.990 1.000 0.970 1.050 1.040 0.980
Compactin1.000 1.060 1.000 1.020 0.930 1.000 1.060
KLA/Compactin1.010 0.930 0.940 1.020 0.950 0.930 0.910
Fut9
KLA  Compactin  Compactin+KLA
 NM_010243 fucosyltransferase 9 (Fut9), mRNA [NM_010243] KLA1.000 1.050 1.190 0.990 0.960 0.950 0.980
Compactin1.000 1.000 0.980 1.010 0.980 0.980 1.020
KLA/Compactin1.020 0.970 1.020 0.990 0.970 0.980 0.970
Gbgt1
KLA  Compactin  Compactin+KLA
 NM_139197 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (Gbgt1), mRNA [NM_139197] KLA0.910 1.030 0.940 0.990 1.010 0.920 0.920
Compactin1.050 1.020 0.950 0.990 1.030 1.020 1.100
KLA/Compactin1.030 1.000 1.010 0.930 1.060 0.910 0.880
Gla
KLA  Compactin  Compactin+KLA
 NM_013463 galactosidase, alpha (Gla), mRNA [NM_013463] KLA1.050 1.070 1.090 0.940 0.920 1.260 1.400
Compactin1.080 1.050 0.980 1.050 0.780 0.650 0.640
KLA/Compactin1.080 1.000 1.030 0.850 0.720 1.000 1.090
Gla
KLA  Compactin  Compactin+KLA
 U34071 alpha-galactosidase A mRNA, complete cds. [U34071] KLA1.040 1.040 0.940 0.880 1.050 1.020 1.080
Compactin0.960 0.940 1.000 0.930 0.810 0.750 0.820
KLA/Compactin1.060 0.970 0.890 0.800 0.950 1.010 0.940
Hexa
KLA  Compactin  Compactin+KLA
 NM_010421 hexosaminidase A (Hexa), mRNA [NM_010421] KLA1.110 0.990 0.970 0.990 0.880 0.850 0.780
Compactin1.180 1.110 1.120 1.170 0.940 0.890 0.700
KLA/Compactin1.180 1.030 0.950 0.980 0.740 0.730 0.680
Hexb
KLA  Compactin  Compactin+KLA
 NM_010422 hexosaminidase B (Hexb), mRNA [NM_010422] KLA1.110 1.030 1.020 0.940 0.600 0.580 0.730
Compactin1.150 1.100 1.100 1.130 1.100 1.040 0.950
KLA/Compactin1.270 1.070 0.920 0.930 0.670 0.590 0.610
Naga
KLA  Compactin  Compactin+KLA
 NM_008669 N-acetyl galactosaminidase, alpha (Naga), mRNA [NM_008669] KLA1.080 1.000 1.090 1.050 1.130 1.150 1.800
Compactin1.150 1.120 1.060 1.040 1.000 1.000 0.970
KLA/Compactin1.150 1.040 1.110 1.110 1.110 1.200 2.080
Sec1
KLA  Compactin  Compactin+KLA
 NM_019934 secretory blood group 1 (Sec1), mRNA [NM_019934] KLA0.970 1.080 0.940 0.970 0.910 0.990 0.980
Compactin1.070 1.020 1.000 1.030 1.050 1.100 1.060
KLA/Compactin0.950 1.030 1.030 1.040 0.980 0.920 0.970
Sec1
KLA  Compactin  Compactin+KLA
 NM_019934 secretory blood group 1 (Sec1), mRNA [NM_019934] KLA0.990 0.980 1.010 0.990 0.930 0.950 0.950
Compactin1.050 0.950 1.000 1.040 0.940 0.990 1.030
KLA/Compactin1.000 0.970 0.970 0.940 1.510 0.860 0.890
St3gal1
KLA  Compactin  Compactin+KLA
 NM_009177 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (St3gal1), mRNA [NM_009177] KLA0.880 1.660 2.650 3.270 2.900 2.790 5.300
Compactin0.890 0.890 0.880 0.860 1.340 1.130 1.000
KLA/Compactin0.960 1.490 2.450 2.820 3.440 4.810 7.850
St3gal2
KLA  Compactin  Compactin+KLA
 NM_009179 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (St3gal2), mRNA [NM_009179] KLA0.950 0.960 0.940 0.900 0.920 0.920 1.050
Compactin1.000 1.020 1.030 1.060 0.980 1.080 1.000
KLA/Compactin1.020 0.970 0.960 0.920 0.900 1.010 0.950
St3gal2
KLA  Compactin  Compactin+KLA
 NM_009179 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (St3gal2), mRNA [NM_009179] KLA1.150 1.090 0.950 0.750 0.790 0.940 0.940
Compactin1.160 1.110 1.070 1.080 1.180 1.070 1.200
KLA/Compactin1.210 0.990 0.870 0.770 0.850 0.970 0.920
St8sia1
KLA  Compactin  Compactin+KLA
 NM_011374 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (St8sia1), mRNA [NM_011374] KLA1.040 1.000 1.000 1.000 0.950 1.080 1.020
Compactin0.960 1.030 1.030 0.990 1.030 1.090 1.070
KLA/Compactin0.990 0.980 0.930 1.000 1.040 0.990 1.060
St8sia1
KLA  Compactin  Compactin+KLA
 NM_011374 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (St8sia1), mRNA [NM_011374] KLA1.100 1.090 1.020 1.100 0.840 0.850 0.800
Compactin1.180 0.970 1.060 1.150 1.170 1.190 1.110
KLA/Compactin1.060 1.010 1.040 1.120 0.930 0.820 0.830