Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Glycosaminoglycan biosynthesis - keratan sulfate (mmu00533)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
B3gnt1
KLA  Compactin  Compactin+KLA
 NM_175383 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3gnt1), mRNA [NM_175383] KLA1.060 0.930 0.850 0.530 0.420 0.570 0.620
Compactin1.000 0.930 0.980 0.980 1.000 0.930 0.820
KLA/Compactin1.090 0.910 0.830 0.490 0.500 0.680 0.550
B3gnt2
KLA  Compactin  Compactin+KLA
 NM_016888 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3gnt2), mRNA [NM_016888] KLA0.920 0.970 1.120 2.620 1.840 1.380 1.270
Compactin0.940 0.880 0.910 0.990 1.050 1.300 1.250
KLA/Compactin1.010 1.020 1.110 2.550 2.060 1.960 1.280
B3gnt2
KLA  Compactin  Compactin+KLA
 NM_016888 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3gnt2), mRNA [NM_016888] KLA0.960 0.950 1.060 2.960 1.830 1.880 1.580
Compactin0.960 0.920 1.040 1.030 1.370 1.490 1.280
KLA/Compactin0.950 0.970 1.060 2.680 2.710 1.560 1.300
B3gnt7
KLA  Compactin  Compactin+KLA
 AK042632 7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730012C22 product:unclassifiable, full insert sequence. [AK042632] KLA1.040 0.950 1.030 1.010 0.960 0.950 1.010
Compactin0.960 1.080 0.980 1.060 0.970 1.030 0.990
KLA/Compactin0.970 0.950 1.060 0.990 0.880 0.980 0.950
B3gnt7
KLA  Compactin  Compactin+KLA
 NM_145222 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3gnt7), mRNA [NM_145222] KLA1.030 0.960 1.050 1.020 0.980 1.020 1.040
Compactin0.930 1.060 1.010 0.980 1.000 1.030 0.940
KLA/Compactin0.930 0.990 1.010 0.960 1.000 1.030 1.010
B4galt1
KLA  Compactin  Compactin+KLA
 NM_022305 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1), mRNA [NM_022305] KLA0.870 0.850 0.650 0.510 0.750 0.750 0.770
Compactin0.810 0.910 0.960 0.870 1.110 1.040 0.900
KLA/Compactin0.970 0.790 0.820 0.470 0.740 0.800 0.880
B4galt1
KLA  Compactin  Compactin+KLA
 NM_022305 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1), mRNA [NM_022305] KLA0.890 0.790 0.820 0.480 0.930 0.680 0.920
Compactin0.970 0.920 0.810 0.850 1.400 1.020 0.880
KLA/Compactin0.940 0.840 0.620 0.450 0.760 1.040 1.200
B4galt1
KLA  Compactin  Compactin+KLA
 NM_022305 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1), mRNA [NM_022305] KLA1.000 1.100 1.030 0.990 1.030 1.140 1.240
Compactin0.970 0.950 0.990 0.980 0.990 1.040 1.050
KLA/Compactin0.900 1.060 0.950 1.060 0.980 1.070 1.210
B4galt2
KLA  Compactin  Compactin+KLA
 NM_017377 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (B4galt2), mRNA [NM_017377] KLA0.880 0.920 1.020 1.070 1.010 1.210 0.930
Compactin0.990 1.110 0.970 1.010 1.000 0.940 0.960
KLA/Compactin0.930 1.020 1.000 0.990 1.030 1.040 1.020
B4galt2
KLA  Compactin  Compactin+KLA
 NM_017377 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (B4galt2), mRNA [NM_017377] KLA1.010 1.050 0.990 1.030 0.960 1.000 0.950
Compactin0.910 1.020 0.960 0.960 0.980 1.030 0.900
KLA/Compactin0.930 1.170 1.010 0.970 0.970 1.010 0.970
B4galt3
KLA  Compactin  Compactin+KLA
 BC021830 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3, mRNA (cDNA clone IMAGE:3978260), **** WARNING: chimeric clone ****. [BC021830] KLA0.980 0.990 0.990 1.050 0.920 1.030 0.890
Compactin0.980 1.030 0.960 0.980 0.940 0.970 0.970
KLA/Compactin1.010 0.980 0.980 0.970 1.020 1.020 0.870
B4galt3
KLA  Compactin  Compactin+KLA
 NM_020579 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 (B4galt3), mRNA [NM_020579] KLA0.960 1.130 0.970 1.800 2.120 2.070 2.060
Compactin1.070 0.950 0.900 0.980 0.930 0.960 1.200
KLA/Compactin1.040 1.060 0.900 1.980 2.290 2.310 2.190
B4galt4
KLA  Compactin  Compactin+KLA
 NM_019804 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 (B4galt4), mRNA [NM_019804] KLA1.030 0.960 1.060 1.020 0.990 0.990 0.970
Compactin1.010 1.060 1.040 0.960 0.980 1.070 1.020
KLA/Compactin0.970 0.950 1.000 1.020 1.060 0.990 1.090
Chst1
KLA  Compactin  Compactin+KLA
 NM_023850 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (Chst1), mRNA [NM_023850] KLA1.000 0.970 0.820 0.820 0.670 0.620 0.750
Compactin0.920 1.040 0.950 1.060 1.140 1.150 1.170
KLA/Compactin0.980 1.040 0.890 0.850 0.720 0.840 0.880
Chst2
KLA  Compactin  Compactin+KLA
 NM_018763 carbohydrate sulfotransferase 2 (Chst2), mRNA [NM_018763] KLA1.000 1.000 1.000 1.010 1.030 1.000 1.040
Compactin1.080 1.010 1.000 1.050 1.100 1.050 0.970
KLA/Compactin1.040 1.000 1.030 0.930 1.040 0.960 0.990
Chst2
KLA  Compactin  Compactin+KLA
 NM_018763 carbohydrate sulfotransferase 2 (Chst2), mRNA [NM_018763] KLA1.030 0.980 1.000 1.000 0.960 1.070 1.040
Compactin0.950 0.970 0.940 1.040 0.950 0.990 0.970
KLA/Compactin0.980 0.980 1.060 0.990 0.950 0.970 1.010
Chst2
KLA  Compactin  Compactin+KLA
 NM_018763 carbohydrate sulfotransferase 2 (Chst2), mRNA [NM_018763] KLA1.030 0.990 1.030 1.030 1.020 0.980 0.990
Compactin1.010 1.010 1.010 0.980 1.080 1.010 0.970
KLA/Compactin1.060 1.050 0.980 0.970 1.030 0.990 1.050
Chst4
KLA  Compactin  Compactin+KLA
 NM_011998 carbohydrate (chondroitin 6/keratan) sulfotransferase 4 (Chst4), mRNA [NM_011998] KLA1.000 0.910 0.930 1.150 0.940 0.970 0.930
Compactin0.970 0.990 0.950 0.970 0.970 1.120 0.910
KLA/Compactin1.100 0.970 1.010 1.100 0.980 1.080 1.070
Chst5
KLA  Compactin  Compactin+KLA
 AF176840 intestine N-acetylglucosamine 6-O-sulfotransferase (I-GlcNAc-6-ST) mRNA, complete cds. [AF176840] KLA1.000 0.930 0.960 0.990 0.980 1.150 0.970
Compactin0.900 0.970 1.020 1.050 0.940 0.970 1.040
KLA/Compactin0.980 0.970 0.970 1.000 0.990 0.960 1.050
Fut8
KLA  Compactin  Compactin+KLA
 NM_016893 fucosyltransferase 8 (Fut8), mRNA [NM_016893] KLA0.900 1.020 0.920 0.900 0.950 0.940 0.850
Compactin0.910 0.920 0.950 0.950 0.900 0.890 0.870
KLA/Compactin0.990 1.020 0.870 0.960 0.990 0.970 0.870
Fut8
KLA  Compactin  Compactin+KLA
 NM_016893 fucosyltransferase 8 (Fut8), mRNA [NM_016893] KLA0.920 0.970 0.920 0.940 0.930 0.920 0.890
Compactin0.870 0.990 0.930 0.950 0.930 0.960 0.940
KLA/Compactin0.980 0.920 0.960 0.860 1.010 1.170 0.890
Fut8
KLA  Compactin  Compactin+KLA
 NM_016893 fucosyltransferase 8 (Fut8), mRNA [NM_016893] KLA0.930 0.980 0.870 0.910 0.930 0.950 0.830
Compactin0.980 1.020 0.960 0.930 0.860 0.880 0.830
KLA/Compactin1.010 0.890 0.950 0.950 1.040 0.950 0.850
St3gal1
KLA  Compactin  Compactin+KLA
 NM_009177 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (St3gal1), mRNA [NM_009177] KLA0.880 1.660 2.650 3.270 2.900 2.790 5.300
Compactin0.890 0.890 0.880 0.860 1.340 1.130 1.000
KLA/Compactin0.960 1.490 2.450 2.820 3.440 4.810 7.850
St3gal2
KLA  Compactin  Compactin+KLA
 NM_009179 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (St3gal2), mRNA [NM_009179] KLA0.950 0.960 0.940 0.900 0.920 0.920 1.050
Compactin1.000 1.020 1.030 1.060 0.980 1.080 1.000
KLA/Compactin1.020 0.970 0.960 0.920 0.900 1.010 0.950
St3gal2
KLA  Compactin  Compactin+KLA
 NM_009179 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (St3gal2), mRNA [NM_009179] KLA1.150 1.090 0.950 0.750 0.790 0.940 0.940
Compactin1.160 1.110 1.070 1.080 1.180 1.070 1.200
KLA/Compactin1.210 0.990 0.870 0.770 0.850 0.970 0.920
St3gal3
KLA  Compactin  Compactin+KLA
 NM_009176 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (St3gal3), mRNA [NM_009176] KLA0.920 0.880 1.000 1.200 1.010 0.970 1.280
Compactin0.960 0.930 0.980 1.060 0.960 1.100 0.980
KLA/Compactin1.000 0.930 0.940 1.260 1.080 1.110 1.210
St3gal3
KLA  Compactin  Compactin+KLA
 NM_009176 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (St3gal3), mRNA [NM_009176] KLA1.090 1.180 1.100 1.640 0.990 0.990 1.020
Compactin1.070 1.150 1.010 1.060 1.000 0.880 0.900
KLA/Compactin1.070 1.170 1.080 1.680 1.000 0.870 1.050