Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Ubiquinone and other terpenoid-quinone biosynthesis (mmu00130)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
Coq2
KLA  Compactin  Compactin+KLA
 NM_027978 coenzyme Q2 homolog, prenyltransferase (yeast) (Coq2), mRNA [NM_027978] KLA0.980 0.930 0.880 0.940 1.050 0.960 0.940
Compactin0.930 0.900 1.010 0.830 0.930 0.970 1.120
KLA/Compactin0.930 0.990 0.920 0.960 0.930 0.930 0.930
Coq3
KLA  Compactin  Compactin+KLA
 27369991 coenzyme Q3 homolog, methyltransferase (yeast) KLA0.990 1.140 1.030 1.020 0.940 0.900 0.920
Compactin1.080 1.030 0.980 1.000 0.960 1.020 1.070
KLA/Compactin1.010 1.020 1.070 1.070 0.970 1.040 0.920
Coq3
KLA  Compactin  Compactin+KLA
 NM_172687 coenzyme Q3 homolog, methyltransferase (yeast) (Coq3), mRNA [NM_172687] KLA0.990 0.970 1.050 0.960 0.990 1.030 0.960
Compactin1.020 1.010 1.070 1.070 1.010 0.990 1.120
KLA/Compactin1.030 0.910 1.060 1.070 0.970 0.930 0.990
Coq5
KLA  Compactin  Compactin+KLA
 NM_026504 coenzyme Q5 homolog, methyltransferase (yeast) (Coq5), mRNA [NM_026504] KLA1.030 0.990 1.190 1.210 1.140 1.430 2.180
Compactin1.150 1.020 1.110 1.250 1.030 1.090 1.070
KLA/Compactin1.120 1.150 1.130 1.220 1.210 1.410 1.920
Coq5
KLA  Compactin  Compactin+KLA
 NM_026504 coenzyme Q5 homolog, methyltransferase (yeast) (Coq5), mRNA [NM_026504] KLA1.040 1.000 1.040 1.070 1.080 1.020 1.590
Compactin1.230 1.020 0.980 1.220 1.020 0.960 0.870
KLA/Compactin1.170 1.080 1.170 1.040 0.980 1.080 1.630
Coq6
KLA  Compactin  Compactin+KLA
 NM_172582 coenzyme Q6 homolog (yeast) (Coq6), mRNA [NM_172582] KLA0.910 0.990 1.030 1.070 0.780 0.870 1.140
Compactin1.070 0.910 1.010 1.070 1.030 1.020 0.900
KLA/Compactin0.910 0.960 1.010 1.040 0.990 0.840 1.080
Coq7
KLA  Compactin  Compactin+KLA
 NM_009940 demethyl-Q 7 (Coq7), mRNA [NM_009940] KLA0.780 0.910 0.870 0.970 0.880 0.580 0.820
Compactin0.920 0.930 0.890 0.750 0.910 1.030 0.790
KLA/Compactin0.830 1.020 0.940 0.920 0.610 0.530 0.810
Coq7
KLA  Compactin  Compactin+KLA
 NM_009940 demethyl-Q 7 (Coq7), mRNA [NM_009940] KLA1.020 1.040 1.140 1.070 0.870 0.750 0.870
Compactin1.110 1.050 1.140 1.180 1.020 0.890 0.800
KLA/Compactin1.080 1.160 1.100 1.160 0.800 0.600 0.740
Ggcx
KLA  Compactin  Compactin+KLA
 NM_019802 gamma-glutamyl carboxylase (Ggcx), mRNA [NM_019802] KLA1.180 0.960 1.060 0.980 0.890 0.920 1.100
Compactin1.130 1.070 1.080 1.010 1.080 1.040 0.990
KLA/Compactin1.160 0.940 1.040 1.000 0.880 0.820 1.010
Hpd
KLA  Compactin  Compactin+KLA
 NM_008277 4-hydroxyphenylpyruvic acid dioxygenase (Hpd), mRNA [NM_008277] KLA1.020 0.960 1.010 1.010 0.990 0.910 0.960
Compactin1.100 1.020 1.030 0.980 0.990 1.040 0.970
KLA/Compactin0.920 1.030 1.080 1.020 0.950 1.020 0.980
Nqo1
KLA  Compactin  Compactin+KLA
 NM_008706 NAD(P)H dehydrogenase, quinone 1 (Nqo1), mRNA [NM_008706] KLA1.090 0.990 1.040 1.020 0.950 1.020 1.000
Compactin1.220 1.090 0.950 0.960 1.010 1.050 1.190
KLA/Compactin1.140 0.890 0.980 0.910 1.000 0.990 0.990
Tat
KLA  Compactin  Compactin+KLA
 NM_146214 tyrosine aminotransferase (Tat), nuclear gene encoding mitochondrial protein, mRNA [NM_146214] KLA1.110 0.960 1.040 1.030 1.040 1.020 1.050
Compactin0.940 0.890 1.010 1.030 1.040 1.080 0.980
KLA/Compactin0.980 1.030 1.080 1.070 1.030 1.130 1.110
Vkorc1
KLA  Compactin  Compactin+KLA
 NM_178600 vitamin K epoxide reductase complex, subunit 1 (Vkorc1), mRNA [NM_178600] KLA0.900 0.940 0.760 0.930 0.680 0.420 0.400
Compactin0.870 0.980 0.910 0.930 1.020 1.040 0.870
KLA/Compactin0.910 0.990 0.880 0.760 0.510 0.440 0.440