Microarray analysis of RAW 264.7 cells treated with Kdo2-lipid A (KLA) and compactin (full time course)

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Kdo2-Lipid A / compactin gene array data - treatment:control ratios

KEGG pathway: Synthesis and degradation of ketone bodies (mmu00072)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 30min 1hr 2hr 4hr 8hr 12hr 24hr
Acat1
KLA  Compactin  Compactin+KLA
 118130035 acetyl-Coenzyme A acetyltransferase 1 KLA0.990 1.040 0.990 0.950 1.030 0.910 0.970
Compactin1.040 1.040 0.960 0.990 1.100 0.980 1.050
KLA/Compactin1.010 1.040 0.960 0.950 0.980 1.040 0.970
Acat1
KLA  Compactin  Compactin+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA1.060 1.000 1.140 1.120 0.890 0.890 0.650
Compactin1.130 1.130 1.170 1.190 0.980 1.080 1.040
KLA/Compactin1.210 1.040 1.190 1.100 0.950 0.850 0.700
Acat2
KLA  Compactin  Compactin+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA0.990 0.960 0.940 1.000 0.740 0.880 0.980
Compactin0.990 1.060 1.190 1.150 1.100 1.090 0.920
KLA/Compactin0.940 1.030 1.020 1.020 0.870 0.880 0.960
Bdh1
KLA  Compactin  Compactin+KLA
 NM_001122683 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), transcript variant 2, mRNA [NM_001122683] KLA1.040 1.000 1.000 0.890 1.000 1.110 1.210
Compactin1.060 1.030 0.940 1.010 0.950 0.920 0.890
KLA/Compactin1.030 0.960 0.920 0.890 0.960 1.140 1.180
Bdh1
KLA  Compactin  Compactin+KLA
 NM_175177 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_175177] KLA0.850 0.940 0.890 0.810 0.880 1.300 1.720
Compactin0.870 0.900 0.910 1.030 0.940 0.910 0.870
KLA/Compactin0.890 0.950 0.860 0.790 1.040 1.520 1.530
Bdh1
KLA  Compactin  Compactin+KLA
 NM_175177 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_175177] KLA0.940 0.850 0.760 0.750 0.840 1.140 1.490
Compactin0.900 0.910 0.900 0.860 0.990 0.830 0.810
KLA/Compactin0.760 0.950 0.740 1.310 1.000 1.530 1.750
Bdh2
KLA  Compactin  Compactin+KLA
 NM_027208 3-hydroxybutyrate dehydrogenase, type 2 (Bdh2), mRNA [NM_027208] KLA1.030 1.000 1.050 0.990 0.880 0.950 0.990
Compactin1.060 1.010 0.980 0.950 1.020 0.990 0.970
KLA/Compactin1.080 1.030 1.090 0.940 0.920 0.910 0.950
Bdh2
KLA  Compactin  Compactin+KLA
 NM_027208 3-hydroxybutyrate dehydrogenase, type 2 (Bdh2), mRNA [NM_027208] KLA1.180 1.110 1.080 1.320 1.150 1.030 0.720
Compactin1.220 1.320 1.160 1.300 0.910 0.750 0.670
KLA/Compactin1.120 1.140 1.020 1.370 1.060 0.690 0.510
Hmgcl
KLA  Compactin  Compactin+KLA
 NM_008254 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl), mRNA [NM_008254] KLA1.080 0.970 0.880 0.660 1.070 1.170 1.540
Compactin1.190 1.060 0.920 1.210 0.990 0.940 1.030
KLA/Compactin1.260 0.990 0.800 0.750 1.050 1.390 1.390
Hmgcs1
KLA  Compactin  Compactin+KLA
 AK078743 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030402P03 product:similar to hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) (fragment) [Gallus gallus], full insert sequence. [AK078743] KLA3.140 1.680 0.790 0.650 0.960 1.080 1.260
Compactin1.100 1.040 1.110 1.060 1.120 0.940 1.050
KLA/Compactin3.310 2.070 0.950 0.810 1.010 0.870 0.970
Hmgcs1
KLA  Compactin  Compactin+KLA
 NM_145942 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), mRNA [NM_145942] KLA0.940 1.360 1.370 0.850 0.960 0.930 0.940
Compactin1.010 0.940 0.970 1.110 0.990 0.960 0.920
KLA/Compactin1.030 1.190 1.530 0.950 1.190 1.130 1.070
Hmgcs1
KLA  Compactin  Compactin+KLA
 NM_145942 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), mRNA [NM_145942] KLA1.040 1.650 1.880 0.600 0.900 0.890 0.530
Compactin0.910 1.040 1.350 1.360 1.230 1.070 0.920
KLA/Compactin1.280 1.510 2.230 0.930 1.210 0.920 0.550
Hmgcs2
KLA  Compactin  Compactin+KLA
 NM_008256 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2), nuclear gene encoding mitochondrial protein, mRNA [NM_008256] KLA1.010 1.030 0.950 1.020 1.040 1.010 0.960
Compactin0.990 0.990 1.030 0.980 1.090 1.040 0.980
KLA/Compactin1.030 1.040 1.040 0.950 1.000 1.020 0.980
Oxct1
KLA  Compactin  Compactin+KLA
 NM_024188 3-oxoacid CoA transferase 1 (Oxct1), nuclear gene encoding mitochondrial protein, mRNA [NM_024188] KLA0.840 1.030 1.070 0.640 0.720 0.690 0.610
Compactin1.060 1.090 1.060 1.070 1.150 0.860 0.660
KLA/Compactin1.180 1.010 0.970 0.800 0.630 0.810 0.550
Oxct1
KLA  Compactin  Compactin+KLA
 NM_024188 3-oxoacid CoA transferase 1 (Oxct1), nuclear gene encoding mitochondrial protein, mRNA [NM_024188] KLA1.010 1.030 0.970 0.770 0.820 0.820 0.720
Compactin0.910 0.920 0.930 0.910 0.890 0.970 0.810
KLA/Compactin0.940 1.010 0.900 0.820 0.740 0.780 0.910
Oxct1
KLA  Compactin  Compactin+KLA
 NM_024188 3-oxoacid CoA transferase 1 (Oxct1), nuclear gene encoding mitochondrial protein, mRNA [NM_024188] KLA1.080 0.990 1.060 0.810 0.850 0.800 0.740
Compactin1.150 1.120 1.050 1.300 1.020 1.000 0.700
KLA/Compactin1.210 1.000 1.090 0.870 0.830 0.900 0.810
Oxct2a
KLA  Compactin  Compactin+KLA
 NM_022033 3-oxoacid CoA transferase 2A (Oxct2a), mRNA [NM_022033] KLA1.010 1.000 0.960 0.940 0.980 1.010 0.930
Compactin0.930 0.940 1.070 1.010 0.990 1.050 1.000
KLA/Compactin1.010 0.930 1.030 0.980 0.970 0.930 1.000
Oxct2a
KLA  Compactin  Compactin+KLA
 NM_022033 3-oxoacid CoA transferase 2A (Oxct2a), mRNA [NM_022033] KLA1.020 1.050 1.040 0.960 0.990 0.930 1.060
Compactin0.970 1.020 0.930 1.030 1.050 1.000 0.960
KLA/Compactin1.010 0.980 1.050 0.840 0.980 0.960 1.030
Oxct2b
KLA  Compactin  Compactin+KLA
 160358826 3-oxoacid CoA transferase 2B KLA1.050 0.990 0.980 1.040 1.030 0.970 0.950
Compactin1.030 1.020 1.030 1.040 1.010 0.990 0.940
KLA/Compactin0.970 0.950 1.000 0.980 1.000 1.010 1.030