Lipidomics Studies on Bone Marrow-derived Macrophages Treated with ATP / Kdo2-Lipid A
Glycerophospholipids
|
Induction
| Details | Graph | LM_ID | Name | Kdo+ATP Kdo ATP 15 min |
Kdo+ATP Kdo ATP 30 min |
Kdo+ATP Kdo ATP 1 hr |
Kdo+ATP Kdo ATP 2 hrs |
Kdo+ATP Kdo ATP 4 hrs |
Kdo+ATP Kdo ATP 8 hrs |
Kdo+ATP Kdo ATP 20 hrs |
|---|---|---|---|---|---|---|---|---|---|---|
 |
Legend:
 :Ctrl
 :Kdo2-lipid A
 :ATP
 :ATP+Kdo2-lipid A
| - | DNA | 1.01
1.06
1.03
| 0.982
0.83
0.973
| 0.804
1.04
0.965
| 0.673
0.766
0.717
| 0.548
1.09
0.812
| 0.739
0.784
0.876
| 0.648
1.07
0.916
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | LPC(16:0) | 1.34
0.966
1.14
| 2.13
0.471
1.41
| 1.03
0.815
1.07
| 0.836
0.816
1.03
| 1.26
1.18
0.912
| 1.46
1.02
1.19
| 0.846
0.843
0.697
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | LPC(18:0) | 0.308
0.484
-
| 5.97
2.12
6.97
| 1.31
0.927
1.14
| 0.549
0.367
0.858
| 0.662
1.03
0.92
| 1.31
0.773
0.852
| 0.923
0.606
0.475
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | LPE(16:0) | 0.976
0.5
0.512
| 0.546
0.536
0.563
| 0.622
1.04
0.791
| 1.03
1.83
1.43
| 1.68
1.42
1.01
| 0.748
0.869
0.737
| 1.08
0.812
0.914
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | LPE(18:0) | 1.73
1.22
1.22
| 0.964
0.74
0.873
| 0.984
1.55
1.49
| 0.924
0.902
1.38
| 1.03
1.07
1.04
| 0.929
0.799
0.778
| 0.931
1.09
0.657
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | LPE(18:1) | 0.541
0.775
0.649
| 1.41
1.05
0.966
| 1.03
1.04
1.49
| 2.46
1.71
1.86
| 1.74
1.48
1.05
| 0.886
0.791
0.991
| 1.16
0.745
0.781
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | LPE(20:4) | 0.551
0.919
0.762
| 1.37
1.02
0.853
| 0.842
1.06
1.17
| 2.38
1.34
2.1
| 1.27
2
0.93
| 1.15
0.72
0.977
| 1.14
0.876
0.888
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | LPE(22:5) | 0.589
0.747
0.695
| 1.95
1.65
1.24
| 0.86
0.914
1.43
| 1.94
1.24
1.67
| 1.01
1.7
0.736
| 1.11
0.836
0.92
| 1.17
0.764
0.767
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | LPE(22:6) | 0.645
0.869
0.79
| 1.07
0.893
0.74
| 0.597
0.957
1.23
| 1.98
1.44
2.04
| 1.17
1.68
0.684
| 1.03
1.05
1.06
| 1.15
0.904
0.879
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | LPI(20:4) | 1.16
0.506
0.721
| 3.5
1.07
2.06
| 2.18
0.968
1.33
| 0.811
1.26
1.16
| 1.2
1.14
-
| 1.14
1.55
1.12
| 1.31
1.79
0.932
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PA(32:0) | 1.76
0.944
1.34
| 2.41
0.804
1.69
| 2.07
1.19
2.06
| 2.22
1.64
2.6
| 1.07
1.38
1.23
| 1.13
1.4
1.21
| 0.763
2.78
1.23
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PA(32:1) | 1.79
0.877
1.51
| 2.26
0.755
1.76
| 3.02
1.26
2.18
| 2.21
1.45
2.89
| 1.39
1.17
1.42
| 1.43
1.22
1.33
| 0.737
2.04
0.882
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PA(34:0) | 1.21
1.06
0.976
| 2.09
1.14
1.55
| 2.02
1.7
2.07
| 1.56
1.26
1.92
| 1.52
1.73
1.65
| 1.07
1.46
1.05
| 0.763
1.81
1.19
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PA(34:1) | 2.36
1.24
1.8
| 2.53
0.965
1.49
| 2.27
1.2
1.89
| 1.98
1.39
1.78
| 1.19
1.25
1.06
| 1.22
1.32
1.36
| 0.74
1.86
1.11
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PA(34:2) | 1
0.627
0.776
| 2.26
0.812
1.36
| 2.04
1.27
1.69
| 2.71
1.45
3.25
| 1.61
1.21
1.54
| 1.33
1.02
1.15
| 1.05
1.05
1
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PA(36:0) | 0.869
0.937
0.767
| 1.36
0.865
1.5
| 1.77
1.45
1.72
| 1.52
1.44
2.07
| 1.28
1.46
1.28
| 1.47
0.966
1.77
| 1.03
1.03
0.97
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PA(36:1) | 1.31
1.1
1.07
| 1.57
0.965
1.07
| 1.05
1.07
1.03
| 1.37
0.98
1.07
| 0.984
1.09
0.794
| 1.64
1.34
1.59
| 1.03
1.13
1.08
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PA(36:2) | 1.6
1.04
1.29
| 2.69
1.25
1.39
| 1.99
1.25
1.76
| 2.13
1.28
1.85
| 1.17
1.34
1.14
| 1.38
1.04
1.37
| 0.801
0.84
0.883
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PA(36:4) | 0.764
0.586
0.612
| 1.95
0.769
1.27
| 2.16
1.54
1.99
| 2.3
1.74
2.99
| 1.62
1.63
1.88
| 1.53
0.771
1.54
| 0.993
0.938
1
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PA(38:4) | 1.69
1.09
1.42
| 3.04
0.99
1.74
| 2.07
1.3
2.1
| 2.18
1.51
2.24
| 1.34
1.22
1.39
| 1.5
1.19
1.66
| 0.912
0.94
0.891
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(28:0) | 1.02
0.614
2.5
| 1.46
0.45
0.574
| 0.561
1.18
0.908
| 3.85
1.03
7.21
| 1.77
0.928
0.455
| 1.79
2.11
2.55
| 1.33
1.76
1.39
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(32:0) | 2.16
1.32
1.07
| 1.06
0.701
0.583
| 0.616
1.21
0.895
| 2.2
1.86
1.5
| 1.35
1.09
0.89
| 1.72
1.46
1.39
| 1.09
1.7
1.36
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(32:1) | 1.47
1.56
1.52
| 1.45
0.77
0.672
| 0.533
0.646
0.595
| 1.06
1.08
0.876
| 1.77
1.43
1.3
| 0.853
0.784
0.694
| 0.583
0.77
0.791
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(32:2) | 1.11
1.37
1.38
| 0.947
0.862
0.708
| 0.849
0.724
0.745
| 1.15
1.52
2.37
| 2.24
1.07
0.739
| 0.937
0.768
1.13
| 0.717
0.7
1.03
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(34:1) | 1.38
1.17
1.19
| 0.964
0.702
0.752
| 0.754
1.04
0.733
| 2.18
1.61
1.09
| 1.39
0.799
1.01
| 1.57
1.08
1.33
| 0.667
0.858
0.834
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(34:2) | 1.59
1.14
1.2
| 1.06
0.701
0.776
| 0.713
0.958
0.743
| 2.09
1.48
1.45
| 1.32
0.958
0.901
| 1.45
0.861
1.39
| 0.622
0.805
0.829
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(34:3) | 0.673
0.957
0.469
| 0.799
0.74
0.763
| 0.523
0.403
0.399
| 3.03
0.833
0.66
| 1.86
1.1
1.21
| 0.553
0.413
0.422
| 5.47
2.71
1.18
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(36:0) | 9.43
3.13
4.21
| 14.8
1.11
1.74
| 0.336
1.96
0.332
| 4.63
2.3
7.13
| 2.34
1.49
1.89
| 0.424
0.916
0.525
| 0.509
0.417
0.527
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(36:1) | 1.02
1.2
0.884
| 0.979
0.814
0.677
| 0.517
0.826
0.625
| 1.76
1.89
1.37
| 1.49
1.15
0.97
| 1.37
1.04
1.16
| 0.676
0.985
0.838
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(36:2) | 1.22
1.11
0.876
| 0.998
0.681
0.757
| 0.714
0.996
0.645
| 1.73
1.63
1.13
| 1.26
1
0.982
| 1.38
0.871
0.947
| 0.484
0.673
0.585
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(36:2e)/PC(36:1p) | 1.05
1.49
1.62
| 1.06
0.732
0.6
| 0.826
0.826
0.914
| 2.24
1.47
1.23
| 0.875
0.924
0.733
| 1.17
0.807
1.12
| 0.544
0.536
0.573
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(36:3) | 1.02
1.2
0.979
| 1.08
0.717
0.843
| 0.667
0.743
0.671
| 1.22
1.08
1.13
| 2.58
1.09
1.52
| 1.33
0.912
0.991
| 0.651
0.55
0.679
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(36:3e)/PC(36:2p) | 2.48
1.84
2.36
| 1.08
0.545
0.784
| 0.727
0.662
0.632
| 3.89
1.39
1.82
| 2.91
1.26
0.782
| 0.949
0.692
0.857
| 0.59
0.455
0.544
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(36:4) | 1.22
1.25
1.21
| 1.47
0.835
1.03
| 0.794
0.752
0.738
| 2.25
1.44
1.14
| 2.03
0.927
1.11
| 1.78
1.02
1.13
| 0.446
0.446
0.507
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(36:4e)/PC(36:3p) | 0.916
1.74
1.75
| 0.902
0.459
0.447
| 0.849
0.704
0.669
| 3.5
1.38
2.77
| 1.93
0.768
0.933
| 1.94
0.671
1.08
| 0.566
0.258
0.392
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(36:5e)/PC(36:4p) | 1.9
1.12
1.07
| 0.653
1.06
0.683
| 2.89
0.599
0.924
| 2.72
1.4
1.47
| 2.56
2.04
1.26
| 1.81
0.961
1.36
| 1.4
1.83
0.938
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(38:3) | 2.27
1.28
1.88
| 1.49
0.673
0.356
| 0.841
1.58
1.32
| 1.62
1.67
2.41
| 2.39
1.75
1.1
| 0.541
0.538
0.656
| 0.516
0.506
0.618
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(38:4) | 0.948
1.32
0.787
| 0.949
0.651
0.577
| 0.663
0.694
0.597
| 1.2
1.4
1.19
| 2.65
1.43
1.2
| 1.55
0.941
0.985
| 0.512
0.422
0.581
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(38:5) | 0.964
1.22
0.891
| 1.37
0.81
0.761
| 0.714
0.891
0.709
| 1.59
1.91
1.21
| 1.92
1.33
1.02
| 1.13
0.685
0.819
| 0.584
0.496
0.628
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(38:5e)/PC(38:4p) | 1.74
1.45
2.26
| 1.35
0.864
0.419
| 0.935
0.696
1.19
| 1.37
1.3
1.28
| 2.22
1.47
1.27
| 1.63
1.16
1.24
| 0.586
0.782
0.842
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(38:6) | 1.44
1.32
1.3
| 1.41
0.876
0.761
| 0.958
1.09
0.911
| 1.92
1.64
1.55
| 1.7
1.06
1.18
| 1.62
0.979
1.42
| 0.637
0.684
0.812
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(38:6e)/PC(38:5p) | 1.39
2.96
1.62
| 2.12
1.05
1.07
| 1.28
0.52
0.814
| 1.46
1.04
0.857
| 1.95
1.17
1.3
| 0.946
0.783
0.826
| 0.504
0.727
0.875
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(40:4) | 0.75
1.47
2.6
| 1.93
0.683
0.961
| 1.68
0.802
0.51
| 3.28
1.39
4.58
| 2.62
2.83
1.75
| 1.05
0.719
1.09
| 0.592
0.559
0.572
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(40:5) | 0.955
1.06
0.922
| 1.05
0.689
0.668
| 1.17
0.93
0.607
| 3
1.86
2.5
| 2.12
2.43
1.09
| 1.58
0.866
0.937
| 0.717
0.689
0.612
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PC(40:6) | 1.8
1.45
1.69
| 1.15
0.974
0.546
| 0.754
0.764
0.496
| 1.74
1.31
1.68
| 1.67
0.786
0.881
| 0.997
0.766
0.729
| 0.535
0.628
0.849
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(32:0) | 1.07
1.58
1.94
| 2.53
0.844
0.543
| 0.839
1.25
0.915
| 4.94
2.07
5.43
| 2.02
1.16
1.18
| 0.634
1.16
1.13
| 2.23
1.41
1.46
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(32:1) | 1.28
1.09
1.65
| 1.77
0.98
0.854
| 0.991
1.13
0.978
| 2.25
1.9
1.89
| 1.32
1.33
1.04
| 0.997
1.58
0.848
| 1.63
1.55
1.42
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(34:0) | 0.912
0.859
1.18
| 1.5
1.23
0.637
| 1.61
1.65
1.37
| 3.96
0.91
1.54
| 0.834
2.63
1.15
| 0.772
0.775
0.398
| 2.17
3.28
2.09
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(34:1) | 1.06
0.73
1.02
| 1.09
1.17
0.809
| 1.18
1.09
1.02
| 1.81
1.63
1.08
| 1.19
1.33
0.879
| 1.21
1.18
1.02
| 0.955
1.38
0.918
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(34:2) | 1.21
0.836
1.33
| 1.33
1.03
0.764
| 1.32
1.43
1.26
| 2.21
1.55
1.35
| 1.68
1.23
1.37
| 1.18
1.25
1.05
| 0.873
1.35
1.29
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(36:0) | 0.976
0.929
0.819
| 0.862
1.1
0.786
| 0.984
1.07
0.906
| 1.07
1.46
1.12
| 1.07
0.717
0.908
| 1.23
1.13
1.1
| 1.04
1.08
0.963
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(36:1) | 0.896
0.865
0.985
| 1.34
1.48
0.976
| 1.24
1.16
1.08
| 1.5
1.4
1.14
| 1.28
1.26
0.923
| 1.29
1.14
1.25
| 0.929
1.1
0.895
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(36:1e)/PE(36:0p) | 1.02
1.2
1.01
| 3.1
2.62
1.64
| 1.25
1.06
0.885
| 2.23
0.817
0.961
| 1.1
1.27
1.65
| 1.09
1
1.18
| 0.856
0.797
0.696
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(36:2) | 0.898
0.812
1.06
| 1.25
1.39
0.853
| 1.2
1.12
1.1
| 1.46
1.46
1.05
| 1.17
1.26
0.879
| 1.1
1.03
1.06
| 0.755
0.939
0.84
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(36:2e)/PE(36:1p) | 1.23
1.02
1.12
| 0.895
0.921
0.783
| 1.12
1.15
0.703
| 1.09
1.47
1.47
| 0.934
0.613
0.868
| 1.29
1.14
1.35
| 1.08
0.959
1.07
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(36:3) | 1.2
0.758
1.01
| 1.01
1.16
0.619
| 1.3
0.912
0.828
| 1.46
1.33
0.981
| 1.23
1.64
0.976
| 1.31
1.05
1.11
| 1.09
1.09
0.924
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(36:3e)/PE(36:2p) | 1.11
0.935
1.76
| 1.14
0.973
1.03
| 0.524
0.95
0.676
| 1.22
0.885
0.82
| 1.53
1.18
1.23
| 1.18
1.13
1.21
| 0.93
0.853
1
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(36:4) | 1.08
0.785
1.23
| 1.27
1.19
0.864
| 0.955
0.946
0.792
| 1.29
1.34
1.01
| 1.4
1.63
1.14
| 1.04
0.983
1.13
| 0.806
1.3
1.1
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(36:4e)/PE(36:3p) | 1.27
0.961
1.16
| 1.09
1.04
0.931
| 0.862
1.07
0.718
| 1.84
1.3
1.15
| 1.64
1.23
1.43
| 1.23
1.13
1.14
| 1.01
1
0.94
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(36:5e)/PE(36:4p) | 1.18
0.85
1.04
| 0.969
0.964
0.875
| 1.14
1.05
0.82
| 1.1
1.63
1.48
| 1.13
0.641
0.917
| 1.52
1.22
1.39
| 1.16
0.919
0.895
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(38:3) | 0.565
1.01
0.982
| 1.23
1.35
1.53
| 1.22
1.34
1.15
| 1.08
0.634
0.843
| 1.11
1.24
0.925
| 1.39
1.26
1.36
| 1.05
1.04
0.878
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(38:3e)/PE(38:2p) | 0.863
0.915
0.923
| 1.54
1.23
1.3
| 1.04
1.07
0.486
| 1.12
0.665
0.95
| 1.14
0.979
0.977
| 1.15
0.927
0.833
| 0.992
0.804
0.924
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(38:4) | 0.878
0.949
0.851
| 1.35
1.46
1.01
| 1.06
1.2
0.96
| 1.41
1.28
1.25
| 1.08
1.19
0.914
| 1.22
1.1
1.27
| 0.927
1.09
0.828
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(38:5) | 0.873
0.807
0.746
| 1.31
1.53
1.04
| 0.959
0.953
0.988
| 1.45
1.29
1.06
| 1.15
1.31
0.917
| 1.13
1.04
1.12
| 0.7
1.05
0.762
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(38:5e)/PE(38:4p) | 1.11
0.942
1.12
| 0.826
0.765
0.701
| 1.22
1.34
0.662
| 0.881
1.18
0.985
| 0.807
0.672
0.824
| 1.24
1.12
1.02
| 1.31
1.16
1.07
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(38:6) | 0.706
0.777
0.819
| 1.44
1.42
0.977
| 1.17
0.836
0.574
| 1.7
1.35
1.16
| 1.92
1.46
1.27
| 1.22
1.15
0.776
| 1.18
1.03
1.22
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(38:6e)/PE(38:5p) | 1.02
0.896
1.06
| 0.981
0.69
0.729
| 0.857
1
0.637
| 0.834
0.857
0.777
| 1.25
1.02
1.32
| 1.22
1.08
1.08
| 1.15
0.916
0.887
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(40:4) | 0.867
1.03
1
| 1.41
1.52
0.963
| 1.57
1.68
2.26
| 1.27
1.12
1.03
| 0.991
1.22
0.842
| 1.55
1.28
1.52
| 1
1.08
0.815
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(40:5) | 0.775
0.951
0.826
| 1.39
1.5
0.965
| 1.17
1.19
0.878
| 1.05
1.17
1
| 1
1.17
0.721
| 1.34
1.2
1.34
| 1.16
0.954
0.824
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PE(40:6) | 0.793
0.936
0.73
| 1.29
1.45
0.935
| 1.15
1.17
0.981
| 1.25
1.28
1.05
| 1.14
1.2
0.883
| 1.35
1.14
1.36
| 1.1
1.07
0.85
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(34:1) | 1.23
1.14
0.861
| 0.868
0.765
0.567
| 0.978
1.32
1.29
| 1.51
1.03
0.862
| 0.815
1.09
0.906
| 1.14
1.16
1.05
| 1.07
1.59
1.14
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(34:2) | 0.855
0.774
0.786
| 1.06
0.693
0.634
| 0.685
0.911
1
| 1.17
1.03
1.09
| 0.914
1.09
1.22
| 2.84
0.864
1.23
| 0.323
0.404
0.343
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(34:3) | 0.693
0.576
0.625
| 1.11
1.03
0.744
| 0.647
0.804
0.503
| 0.744
0.691
0.454
| 0.971
1.06
0.874
| 1.03
0.881
0.791
| 0.95
0.592
0.636
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(36:0) | 0.963
0.279
0.453
| 1.31
0.444
0.205
| 0.635
0.645
0.446
| 0.517
0.267
0.041
| 0.839
1.31
0.415
| 0.818
1.38
0.499
| 1.69
4.87
3.5
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(36:1) | 0.937
1.1
0.714
| 0.904
0.624
0.622
| 0.616
0.861
0.835
| 0.711
0.567
0.517
| 0.905
1.08
1.01
| 0.856
0.977
0.636
| 0.908
1.71
1.32
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(36:2) | 0.789
0.863
0.717
| 0.991
0.721
0.783
| 0.764
0.972
1.07
| 0.998
0.873
0.811
| 0.995
0.974
0.984
| 1.31
0.861
0.947
| 0.713
0.915
0.823
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(36:3) | 0.789
0.841
0.778
| 1.01
0.78
0.761
| 0.826
0.949
1.01
| 1.41
1.29
1.09
| 1.18
1.11
1.08
| 1.72
1.08
1.32
| 1.17
0.848
0.947
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(36:4) | 0.767
0.72
0.427
| 0.849
0.371
0.314
| 1.38
1.05
1.47
| 0.246
0.219
0.183
| 2.2
1.13
1.22
| 1.79
1.21
0.427
| 1.28
1.65
0.366
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(38:2) | 0.768
0.77
0.699
| 0.969
0.586
0.638
| 0.801
0.865
0.761
| 1.86
1.38
1.52
| 0.923
1.04
0.971
| 0.678
0.771
0.594
| 0.716
1.01
0.947
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(38:3) | 0.858
0.908
0.721
| 0.828
0.579
0.586
| 0.882
0.988
0.882
| 1.9
1.6
1.31
| 1.05
1.06
1.12
| 1.11
0.773
0.704
| 0.943
0.78
0.819
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(38:4) | 0.91
0.957
0.761
| 1.13
0.719
0.722
| 0.878
0.999
0.929
| 1.99
1.59
1.56
| 1.3
1.08
1.31
| 1.43
0.835
0.861
| 1.3
0.764
0.838
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(38:5) | 0.97
1.01
0.699
| 1.06
0.805
0.747
| 0.998
1.06
0.961
| 1.3
1.1
0.751
| 1.23
1.26
1.4
| 1.53
0.909
1.11
| 1.34
0.944
0.703
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(38:6) | 0.896
0.904
0.622
| 1.25
0.622
0.672
| 0.819
0.81
0.681
| 1.09
1.13
0.723
| 1.37
1
1.12
| 0.884
0.823
0.624
| 1.04
0.747
0.588
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(40:4) | 0.754
0.849
0.683
| 1.26
0.523
0.752
| 0.711
0.62
0.504
| 1.02
0.802
0.621
| 0.97
0.955
1.27
| 0.883
0.758
0.529
| 0.788
0.669
0.675
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(40:5) | 0.733
0.632
0.569
| 1.23
0.615
0.594
| 1.01
0.828
0.729
| 1.28
1.02
0.85
| 1.11
1.03
1.33
| 0.569
0.518
0.5
| 0.977
0.741
0.712
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(40:6) | 0.844
0.919
0.762
| 1.48
0.642
0.72
| 0.854
0.864
0.787
| 1.21
1.02
0.872
| 1.3
1.16
1.37
| 1.34
0.836
0.673
| 0.944
0.754
0.719
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(40:7) | 0.777
0.819
0.673
| 1.14
0.745
0.719
| 0.755
0.862
0.815
| 0.928
0.805
0.826
| 1.24
1.09
1.3
| 1.42
0.868
0.798
| 1.05
0.881
0.734
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PG(40:8) | 0.974
0.922
0.602
| 1.36
0.658
0.718
| 0.627
0.776
0.68
| 0.689
0.764
0.526
| 1.22
1.13
0.862
| 0.908
0.895
0.831
| 1.69
0.707
0.709
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(32:1) | 1.47
0.871
1.67
| 4
0.927
0.905
| 1.21
1.19
1.21
| 4.35
3.34
1.72
| 2.92
3.39
4.33
| 0.495
0.62
0.947
| 2.4
0.656
1.54
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(34:0) | 0.611
1.39
3.31
| 3.04
0.302
2.05
| 0.444
2.33
1.2
| 4.81
1.79
3.42
| 3.04
2.46
2.39
| 0.534
0.774
0.458
| 2.24
1.12
1.2
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(34:1) | 0.99
0.783
1.33
| 2.45
0.794
1.38
| 0.969
1.47
1.66
| 2.73
1.55
1.89
| 1.36
1.47
1.41
| 1.08
1.61
1.11
| 0.882
1.42
1.11
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(34:2) | 0.887
0.829
1.5
| 3.1
0.655
1.49
| 0.814
1.33
1.43
| 2.58
1.67
2.98
| 1.52
2.65
1.58
| 0.815
1.13
0.637
| 1.03
0.925
0.864
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(36:0) | 1.03
0.897
2.23
| 1.95
0.327
0.935
| 0.112
1.18
0.811
| 60.9
17.4
17.9
| 3.27
0.206
2.46
| 0.064
1.16
0.086
| 2.46
1.14
0.991
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(36:1) | 0.846
0.776
1.04
| 1.51
0.886
0.993
| 1.03
1.17
1.05
| 1.13
0.653
1.62
| 1.41
1.47
1.19
| 0.895
1.47
1.28
| 1.76
1.77
1.33
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(36:2) | 0.799
0.762
1.03
| 1.36
0.816
0.84
| 1.14
1.12
1.27
| 2.02
1.18
1.69
| 1.25
1.13
1.16
| 0.973
1.21
0.986
| 1.32
1.36
1.02
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(36:3) | 1.02
1.16
1.37
| 1.79
0.898
1.1
| 1.08
1.24
1.23
| 3.03
1.32
1.55
| 0.983
0.874
1.03
| 0.701
0.655
1.27
| 2.03
1.25
1.24
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(36:4) | 0.76
0.88
1.02
| 1.9
0.94
0.881
| 1.2
1.45
1.36
| 2.94
1.12
1.99
| 1.59
2.27
0.991
| 1.05
1.4
1.31
| 0.897
1.72
1.34
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(38:2) | 0.868
0.838
1.22
| 2.31
1.05
1.18
| 1.24
0.795
0.315
| 7.8
4.32
7.01
| 2.39
2.8
2.8
| 0.36
0.589
0.731
| 8.03
1.8
3.23
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(38:3) | 0.589
0.605
0.785
| 1.14
1
0.855
| 1.04
1.07
0.995
| 2.08
1.42
1.69
| 1.23
1.91
1.23
| 0.85
0.758
0.63
| 1.53
1.09
0.901
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(38:4) | 0.554
0.682
0.757
| 0.952
0.936
0.705
| 0.791
0.972
0.964
| 1.65
1.34
1.05
| 1.14
1.35
1.08
| 1.05
0.872
0.803
| 1.44
0.945
0.847
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(38:5) | 0.725
0.778
0.886
| 1.24
0.953
0.784
| 1.06
0.953
1.05
| 1.84
1.14
1.13
| 1.27
1.58
1.23
| 1
0.932
0.916
| 1.36
0.802
0.869
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(40:3) | 2
1.16
1.17
| 1.39
1.11
0.938
| 0.965
3.03
0.765
| 0.49
0.077
0.831
| 0.779
0.763
1.12
| 0.155
0.762
0.812
| 6.41
3.07
1.43
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(40:4) | 0.647
0.466
0.736
| 4.03
0.878
2.23
| 1.29
1.17
1.17
| 10.5
2.34
3.91
| 1.53
1.99
1.53
| 0.715
0.616
0.715
| 2.09
0.728
0.253
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(40:5) | 0.787
0.82
0.956
| 2.15
0.91
1.42
| 0.951
1.01
1.04
| 5.25
1.42
3.38
| 2.02
2.91
1.48
| 0.514
0.795
0.714
| 2.19
1.07
0.445
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PI(40:6) | 0.934
0.744
1.12
| 3.14
0.962
1.2
| 1.53
0.468
1.68
| 4.72
1.57
3.89
| 1.8
0.588
1.36
| 0.588
1.09
0.852
| 2.38
0.759
0.377
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(32:0) | 1.58
1.33
1.2
| 2.43
0.83
0.66
| 0.988
1.32
1.6
| 1.93
0.953
1.68
| 2.14
1.59
1.11
| 1.52
1.59
1.87
| 1.08
1.39
1.32
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(32:1) | 1.76
1.28
1.89
| 1.28
1.28
1.27
| 3.71
2.42
5.24
| 1.14
0.267
0.366
| 1.69
1.19
0.858
| 0.747
1.15
1.39
| 0.453
1.08
0.64
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(34:0) | 2.34
1.6
1.51
| 3.22
2.01
1.17
| -
-
-
| 1.84
2.08
1.73
| 2.22
2.1
1.17
| 1.08
1.7
0.871
| 5.56
3.17
3.74
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(34:1) | 1.26
1.08
1.17
| 1.49
1.06
0.895
| 0.796
0.964
1.39
| 1.5
0.682
1.19
| 1.12
1.16
0.904
| 1.45
1.91
1.16
| 1.35
1.84
1.13
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(36:0) | 1.52
0.85
0.567
| 0.985
2.52
0.787
| 1.88
2.05
1.61
| 2.94
1.06
1.27
| 1.04
3.12
1.06
| 0.416
0.624
0.522
| 0.766
1.06
0.105
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(36:1) | 0.851
1.18
1.01
| 1.43
1.09
0.823
| 1.1
1.14
0.945
| 1.01
0.897
0.89
| 0.929
0.539
0.733
| 2.36
1.29
1.16
| 0.942
1.49
1.27
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(36:2) | 1.24
1.36
1.21
| 1.54
0.987
0.994
| 0.936
0.805
0.98
| 1.83
1.48
2.45
| 1.48
0.756
1.38
| 1.76
2
1.44
| 0.968
0.833
0.837
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(36:4) | 1.76
1.29
1.98
| 1.85
1.24
0.336
| 1.56
4.09
1.31
| 1.29
0.88
0.522
| 1.89
1.24
1.26
| 0.831
1.09
0.707
| 0.783
1.97
1.18
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(38:2) | 1.22
1.05
1.33
| 0.684
0.57
0.678
| 0.922
0.548
0.606
| 1.88
1.11
1.45
| 1.09
0.655
0.708
| 0.766
0.723
0.394
| 2.06
1.26
1.64
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(38:3) | 1.29
1.22
1.08
| 1.54
1.01
0.952
| 0.851
0.995
0.785
| 1.15
1.03
1.23
| 0.862
0.943
1.03
| 1.35
2.12
1.4
| 0.54
1.27
1.42
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(38:4) | 1.17
0.934
1.13
| 1.63
1.41
1.09
| 1.04
1.05
1.08
| 1.57
0.978
1.3
| 1.02
0.487
0.516
| 1.13
1.17
2.08
| 0.92
2.06
1.09
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(38:5) | 1.02
0.803
0.893
| 1.55
0.995
1.05
| 0.878
0.315
0.883
| 1.6
1.21
1.93
| 1.55
0.917
1.18
| 0.45
0.955
0.674
| 1.3
2.11
1.51
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(38:6) | 1.6
0.73
1.08
| 2.15
1.43
2.35
| 4.09
2.06
3.93
| 1.27
0.723
2.04
| 1.42
4.26
1.35
| 0.846
1.38
2.22
| 1.18
2.52
4.54
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(40:4) | 1.11
0.813
0.792
| 1.41
1.08
0.956
| 0.766
0.727
0.66
| 1.99
1.14
1.38
| 0.911
0.777
0.853
| 0.736
1.01
0.99
| 0.838
1.02
1
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(40:5) | 1.3
1.13
1.31
| 1.31
0.702
0.957
| 0.841
0.825
0.767
| 1.55
1.06
1.24
| 0.948
0.852
0.91
| 0.586
0.927
0.632
| 0.829
1.19
1.07
|
|
Legend:
:Ctrl
:Kdo2-lipid A
:ATP
:ATP+Kdo2-lipid A
| - | PS(40:6) | 1.24
1.13
1.25
| 1.5
1.06
0.87
| 0.962
0.99
1.2
| 1.51
1.05
1.28
| 0.876
0.855
0.902
| 0.899
1.06
0.704
| 0.989
1.22
1.29
|