LMPD Database

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LMP006728

Record overview

LMPD IDLMP006728
Gene ID79966
SpeciesHomo sapiens (Human)
Gene Namestearoyl-CoA desaturase 5
Gene SymbolSCD5
SynonymsACOD4; FADS4; HSCD5; SCD2; SCD4
Alternate namesstearoyl-CoA desaturase 5; acyl-CoA-desaturase 4; stearoyl-CoA 9-desaturase; stearoyl-CoA desaturase 4
Chromosome4
Map Location4q21.22
EC Number1.14.19.1
SummaryStearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for SCD5

Proteins

stearoyl-CoA desaturase 5 isoform a
Refseq ID:NP_001032671
Protein GI:148596961
UniProt ID:Q86SK9
mRNA ID:NM_001037582
Length:330
RefSeq Status:VALIDATED
MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQNIVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHR
SYRAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADPVVRIQRKYYKISVVLMC
FVVPTLVPWYIWGESLWNSYFLASILRYTISLNISWLVNSAAHMYGNRPYDKHISPRQNPLVALGAIGEGFHNYHHTFPFDYSASEFGLNFNPTTWFIDF
MCWLGLATDRKRATKPMIEARKARTGDSSA
 
stearoyl-CoA desaturase 5 isoform b
Refseq ID:NP_079182
Protein GI:148596938
UniProt ID:Q86SK9
mRNA ID:NM_024906
Length:256
RefSeq Status:VALIDATED
MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQNIVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHR
SYRAKLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKHRDVIEKGRKLDVTDLLADPVVRIQRNTQHIQKEGRA
LNQEAACEMLREWHQGHILKVTLPGLHILALLHTHCNHSEKCCLMLRALSVSLEVF