LMPD Database

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LMP005547

Record overview

LMPD IDLMP005547
Gene ID4973
SpeciesHomo sapiens (Human)
Gene Nameoxidized low density lipoprotein (lectin-like) receptor 1
Gene SymbolOLR1
SynonymsCLEC8A; LOX1; LOXIN; SCARE1; SLOX1
Alternate namesoxidized low-density lipoprotein receptor 1; hLOX-1; ox LDL receptor 1; lectin-type oxidized LDL receptor 1; scavenger receptor class E, member 1; C-type lectin domain family 8 member A; oxidized low-density lipoprotein receptor 1, soluble form
Chromosome12
Map Location12p13.2-p12.3
SummaryThis gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
OrthologsView orthologs and multiple alignments for OLR1

Proteins

oxidized low-density lipoprotein receptor 1 isoform 1
Refseq ID:NP_002534
Protein GI:4505501
UniProt ID:P78380
mRNA ID:NM_002543
Length:273
RefSeq Status:REVIEWED
MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESEN
ELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSF
PFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ
 
oxidized low-density lipoprotein receptor 1 isoform 2
Refseq ID:NP_001166103
Protein GI:290654342
UniProt ID:P78380
mRNA ID:NM_001172632
Length:181
RefSeq Status:REVIEWED
MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESEN
ELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSGLHPASNFLFQFSILDGAVSEEPQLPMALGGRFSFDAPLI
 
oxidized low-density lipoprotein receptor 1 isoform 3
Refseq ID:NP_001166104
Protein GI:290654344
UniProt ID:P78380
mRNA ID:NM_001172633
Length:189
RefSeq Status:REVIEWED
MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESEN
ELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLI