LMPD Database

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LMP004697

Record overview

LMPD IDLMP004697
Gene ID27052
SpeciesMus musculus(Mouse)
Gene Nameacyloxyacyl hydrolase
Gene SymbolAoah
Synonyms4930433E13Rik
Alternate namesacyloxyacyl hydrolase
Chromosome13
Map Location13 A2|13
EC Number3.1.1.77
SummaryThis genes encodes an enzyme that catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides. The encoded protein modulates host inflammatory response to gram-negative bacteria. The proprotein is further cleaved into a large and small chain that interact in a heterodimer. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for Aoah

Proteins

acyloxyacyl hydrolase isoform 1 preproprotein
Refseq ID:NP_036184
Protein GI:6753064
UniProt ID:O35298
mRNA ID:NM_012054
Length:574
RefSeq Status:REVIEWED
MKFPWKVFKTTLLLLLLSHSLASVPSEDQPGDSYSHGQSCLGCVVLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYFLVQTFGSDIIKLLDEA
MKADVVCYALEFCKRGAVQPQCHLYPLPQEAWESALEKARQVLRRSSTMKYPRSGRNICSLPFLTKICQKIELSIKKAVPFKDIDSDKHSVFPTLRGYHW
RGRDCNDSDKTVYPGRRPDNWDIHQDSNCNGIWGIDPKDGIPYEKKFCEGSQPRGIILLGDSAGAHFHIPPEWLTASQMSVNSFLNLPSALTDELNWPQL
SGVTGFLDSTSGIEEKSIYHRLRKRNHCNHRDYQSISKNGASSRNLKNFIESLSRNQASDHPAIVLYAMIGNDVCNSKADTVPEMTTPEQMYANVMQTLT
HLNSHLPNGSHVILYGLPDGTFLWDSLHNRYHPLGQLNKDVTYAQFFSFLRCLQLNPCNGWMSSNKTLRTLTSERAEQLSNTLKKIATTETFANFDLFYV
DFAFHEIIEDWQKRGGQPWQLIEPVDGFHPNEVASLLQANRVWEKIQLQWPHVLGKENPFNSQIEEVFGDQGGH
 
sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2587
peptide sequence: 
MKFPWKVFKTTLLLLLLSHSLA

sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2587
peptide sequence: 
MKFPWKVFKTTLLLLLLSHSLA

mat_peptide: 34..155
product: acyloxyacyl hydrolase small subunit
calculated_mol_wt: 13749
peptide sequence: 
YSHGQSCLGCVVLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYFLVQTFGSDIIKLLDEAMKADVVCYALEFCKRGAVQPQCHLYPLPQEAWE
SALEKARQVLRRSSTMKYPRSG

mat_peptide: 156..574
product: acyloxyacyl hydrolase large subunit
calculated_mol_wt: 47756
peptide sequence: 
RNICSLPFLTKICQKIELSIKKAVPFKDIDSDKHSVFPTLRGYHWRGRDCNDSDKTVYPGRRPDNWDIHQDSNCNGIWGIDPKDGIPYEKKFCEGSQPRG
IILLGDSAGAHFHIPPEWLTASQMSVNSFLNLPSALTDELNWPQLSGVTGFLDSTSGIEEKSIYHRLRKRNHCNHRDYQSISKNGASSRNLKNFIESLSR
NQASDHPAIVLYAMIGNDVCNSKADTVPEMTTPEQMYANVMQTLTHLNSHLPNGSHVILYGLPDGTFLWDSLHNRYHPLGQLNKDVTYAQFFSFLRCLQL
NPCNGWMSSNKTLRTLTSERAEQLSNTLKKIATTETFANFDLFYVDFAFHEIIEDWQKRGGQPWQLIEPVDGFHPNEVASLLQANRVWEKIQLQWPHVLG
KENPFNSQIEEVFGDQGGH
 
acyloxyacyl hydrolase isoform 2 preproprotein
Refseq ID:NP_001268783
Protein GI:529367294
UniProt ID:O35298
mRNA ID:NM_001281854
Length:145
RefSeq Status:REVIEWED
MKFPWKVFKTTLLLLLLSHSLASVPSEDQPGDSYSHGQSCLGCVVLVSVIEQLAEVHNSSVQVAMERLCSYLPEKLFLKTACYFLVQTFGSDIIKLLDEA
MKADVVCYALEFCKRGAVQPQCHLYPLPQDNQLISRCPERFRDQY