LMPD Database

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LMP004694

Record overview

LMPD IDLMP004694
Gene ID57107
SpeciesHomo sapiens (Human)
Gene Nameprenyl (decaprenyl) diphosphate synthase, subunit 2
Gene SymbolPDSS2
SynonymsC6orf210; COQ10D3; DLP1; bA59I9.3; hDLP1
Alternate namesdecaprenyl-diphosphate synthase subunit 2; decaprenyl pyrophosphate synthase subunit 2; subunit 2 of decaprenyl diphosphate synthase; decaprenyl pyrophosphate synthetase subunit 2; all-trans-decaprenyl-diphosphate synthase subunit 2
Chromosome6
Map Location6q21
EC Number2.5.1.91
SummaryThe protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.[provided by RefSeq, Oct 2009]
OrthologsView orthologs and multiple alignments for PDSS2

Proteins

decaprenyl-diphosphate synthase subunit 2
Refseq ID:NP_065114
Protein GI:169808399
UniProt ID:Q86YH6
mRNA ID:NM_020381
Length:399
RefSeq Status:REVIEWED
MNFRQLLLHLPRYLGASGSPRRLWWSPSLDTISSVGSWRGRSSKSPAHWNQVVSEAEKIVGYPTSFMSLRCLLSDELSNIAMQVRKLVGTQHPLLTTARG
LVHDSWNSLQLRGLVVLLISKAAGPSSVNTSCQNYDMVSGIYSCQRSLAEITELIHIALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANAC
NGLALLQNTKVVELLASALMDLVQGVYHENSTSKESYITDDIGISTWKEQTFLSHGALLAKSCQAAMELAKHDAEVQNMAFQYGKHMAMSHKINSDVQPF
IKEKTSDSMTFNLNSAPVVLHQEFLGRDLWIKQIGEAQEKGRLDYAKLRERIKAGKGVTSAIDLCRYHGNKALEALESFPPSEARSALENIVFAVTRFS