LMPD Database

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LMP003541

Record overview

LMPD IDLMP003541
Gene ID1650
SpeciesHomo sapiens (Human)
Gene Namedolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
Gene SymbolDDOST
SynonymsAGER1; CDG1R; OKSWcl45; OST; OST48; WBP1
Alternate namesdolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; oligosaccharyltransferase subunit 48; advanced glycation endproduct receptor 1; oligosaccharyltransferase 48 kDa subunit; oligosaccharyl transferase 48 kDa subunit; dolichyl-diphosphooligosaccharide-protein glycotransferase
Chromosome1
Map Location1p36.1
EC Number2.4.99.18
SummaryThis gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DDOST

Proteins

dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor
Refseq ID:NP_005207
Protein GI:20070197
UniProt ID:P39656
mRNA ID:NM_005216
Length:456
RefSeq Status:REVIEWED
MGYFRCAGAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCASGPRTLVLLDNLNVRETHSLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIF
SPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGV
GMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVF
KEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYT
HLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKEKEKSD
 
sig_peptide: 1..42
calculated_mol_wt: 4604
peptide sequence: 
MGYFRCAGAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCA

mat_peptide: 43..456
product: dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
calculated_mol_wt: 46116
peptide sequence: 
SGPRTLVLLDNLNVRETHSLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELG
SECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTL
LIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSN
GKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIF
SIVFLHMKEKEKSD