LMPD Database

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LMP003139

Record overview

LMPD IDLMP003139
Gene ID1603
SpeciesHomo sapiens (Human)
Gene Namedefender against cell death 1
Gene SymbolDAD1
SynonymsOST2
Alternate namesdolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; DAD-1; oligosaccharyltransferase 2 homolog; oligosaccharyl transferase subunit DAD1; oligosaccharyltransferase subunit 2 (non-catalytic)
Chromosome14
Map Location14q11.2
EC Number2.4.99.18
SummaryDAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DAD1

Proteins

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Refseq ID:NP_001335
Protein GI:4503253
UniProt ID:P61803
mRNA ID:NM_001344
Length:113
RefSeq Status:REVIEWED
MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFA
STILHLVVMNFVG