LMPD Database

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LMP002851

Record overview

LMPD IDLMP002851
Gene ID6555
SpeciesHomo sapiens (Human)
Gene Namesolute carrier family 10 (sodium/bile acid cotransporter), member 2
Gene SymbolSLC10A2
SynonymsASBT; IBAT; ISBT; NTCP2; PBAM
Alternate namesileal sodium/bile acid cotransporter; Na(+)-dependent ileal bile acid transporter; ileal sodium-dependent bile acid transporter; ileal apical sodium-dependent bile acid transporter; sodium/taurocholate cotransporting polypeptide, ileal; solute carrier family 10 (sodium/bile acid cotransporter family), member 2
Chromosome13
Map Location13q33
SummaryThis gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for SLC10A2

Proteins

ileal sodium/bile acid cotransporter
Refseq ID:NP_000443
Protein GI:4506973
UniProt ID:Q12908
mRNA ID:NM_000452
Length:348
RefSeq Status:REVIEWED
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVV
LIIGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVALVVPVSIGMFVNHKWPQKAKIILKIGSIA
GAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAF
AAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK